Here we present BridgePRS, a novel Bayesian polygenic risk score (PRS) method that
leverages shared genetic effects across ancestries to increase PRS portability. We evaluate …

Background Accurate assessment of health disparities requires unbiased knowledge of
genetic risks in different populations. Unfortunately, most genome-wide association studies …

Early identification of genetic risk factors for complex diseases can enable timely
interventions and prevent serious outcomes, including mortality. While the genetics …

Polygenic risk scores (PRS) use the results of genome-wide association studies (GWAS) to
predict quantitative phenotypes or disease risk at an individual level, and provide a potential …

Studies of the relationship between genetic and phenotypic variation have historically been
carried out on people of European ancestry. Efforts are underway to address this limitation …

Polygenic risk scores suffer reduced accuracy in non-European populations, exacerbating
health disparities. We propose PolyPred, a method that improves cross-population …

Background Polygenic risk scores (PRS) are valuable to translate the results of genome-
wide association studies (GWAS) into clinical practice. To date, most GWAS have been …

Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …

Although the cohort-level accuracy of polygenic risk scores (PRSs)—estimates of genetic
value at the individual level—has been widely assessed, uncertainty in PRSs remains …

One goal of genomic medicine is to uncover an individual's genetic risk for disease, which
generally requires data connecting genotype to phenotype, as done in genome-wide …