Purpose of review A polygenic risk score (PRS) is a measure of genetic liability to a disease
and is typically normally distributed in a population. Individuals in the upper tail of this …

Population stratification can produce spurious genetic associations in genome-wide
association studies (GWASs). Mixed model methodology has been regarded useful for …

Genome-wide association studies (GWAS) have been very successful at identifying genetic
variants influencing a large number of traits. Although the great majority of these studies …

Despite strong transethnic genetic correlations reported in the literature for many complex
traits, the non-transferability of polygenic risk scores across populations suggests the …

Polygenic scores have recently been used to summarise genetic effects among an
ensemble of markers that do not individually achieve significance in a large-scale …

Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision
medicine. However, the major ethical and scientific challenge surrounding clinical …

The past decade has seen a technological revolution in human genetics that has
empowered population-level investigations into genetic associations with phenotypes …

The potential for genome-wide association studies to relate phenotypes to specific genetic
variation is greatly increased when data can be combined or compared across multiple …

Genome-wide association studies of clinically defined cases against controls have
transformed our understanding of the genetic causes of many diseases. However, there are …

Polygenic scores (PGSs) have emerged as a standard approach to predict phenotypes from
genotype data in a wide array of applications from socio-genomics to personalized …