Polygenic risk scores (PRS) based on European training data suffer reduced accuracy in
non-European target populations, exacerbating health disparities. This loss of accuracy …

Whole-genome sequencing harbors unprecedented potential for characterization of
individual and family genetic variation. Here, we develop a novel synthetic human reference …

Population stratification (PS) is a primary consideration in studies of genetic determinants of
human traits. Failure to control for PS may lead to confounding, causing a study to fail for …

We study in this article jointly testing the associations of a genetic variant with correlated
multiple phenotypes using the summary statistics of individual phenotype analysis from …

The use of genomic information to better understand and prevent common complex
diseases has been an ongoing goal of genetic research. Over the past few years, research …

Polygenic risk scores (PRS) leverage the genetic contribution of an individual's genotype to
a complex trait by estimating disease risk. Traditional PRS prediction methods are …

Polygenic risk scores (PRSs) are central to the development of precision medicine.
However, decades of Euro-centric genomics research have paved the way for disparities in …

Polygenic risk scores (PRSs) have become the standard for quantifying genetic liability in
the prediction of disease risks. PRSs are generally constructed as weighted sum scores of …

There has been an increasing interest in joint association testing of multiple traits for
possible pleiotropic effects. However, even in the presence of pleiotropy, most of the existing …

Introductory paragraph The inclusion of genetic data in large studies has enabled the
discovery of genetic contributions to complex traits and their application in applied analyses …