Two hundred and twelve adults with cough and purulent sputum of up to one week's
duration were allocated randomly to treatment with doxycycline or placebo capsules for up …

Investigations both here (Elmes et al., 1953) and elsewhere (Mulder et al., 1952; Stuart-
Harris et al., 1952; May, 1953) have shown that exacerbations of chronic bronchitis are …

Fifty patients with exacerbations of chronic bronchitis were treated with either a combination
of trimethoprim 320 mg. and sulphamethoxazole 1,600 mg. a day or ampicillin 2 g. a day …

Abstract 829 healthy male volunteers aged 20-49 were issued with supplies of either
demethylchlortetracycline or placebo in late October, 1969, with instructions to take a course …

industrial towns, is emphasised by Goodman et al.(1953). Chronic bronchitis causes not
only many deaths but also a serious loss of working-time. Although many of the patients …

The role of antibiotics in bronchitis has been the subject of two previous double-blind
investigations by this committee, carried out by a large number ofchest physicians …

penicillin should be tested as a possible alternative, since Douglas et al.(1957) reported
favourably on this drug in infective exacerbations of chronic bronchitis with purulent sputum …

Methods In view of the improvement in health which resulted from antibiotic medication in
the previous trial, the inclusion in the second trial of a group of patients receiving nothing but …

The concentration of doxycycline hydrochloride was measured in serum and bronchial
secretions in five patients with chronic bronchitis receiving doxycycline orally in normal …

Seventy-nine patients with chronic bronchitis were randomly allotted to four treatment
regimens—placebo throughout the winter months for five years; tetracycline for the first two …