The role of lung macrophages in acute respiratory distress syndrome

W Dang, Y Tao, X Xu, H Zhao, L Zou, Y Li - Inflammation Research, 2022 - Springer
Acute respiratory distress syndrome (ARDS) is an acute and diffuse inflammatory lung injury
in a short time, one of the common severe manifestations of the respiratory system that …

Altered cellular metabolism drives trained immunity

Y Sohrabi, R Godfrey, HM Findeisen - Trends in Endocrinology & …, 2018 - cell.com
Exposing innate immune cells to an initial insult induces a long-term proinflammatory
response due to metabolic and epigenetic alterations which encompass an emerging new …

Immunometabolism: another road to sepsis and its therapeutic targeting

V Kumar - Inflammation, 2019 - Springer
Sepsis is a major health problem all over the world. Despite its existence since the time of
Hippocrates (470 BC), sepsis is still a serious medical problem for physicians working in …

Inhibition of glycolysis alleviates lipopolysaccharide‐induced acute lung injury in a mouse model

WJ Zhong, HH Yang, XX Guan, JB Xiong… - Journal of cellular …, 2019 - Wiley Online Library
Gluconic metabolic reprogramming, immune response, and inflammation are intimately
linked. Glycolysis involves in the pathologic progress in acute and chronic inflammatory …

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

AS Mirchandani, SJ Jenkins, CC Bain… - Nature …, 2022 - nature.com
Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-
fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia …

The role of metabolic enzymes in the regulation of inflammation

WH Godfrey, MD Kornberg - Metabolites, 2020 - mdpi.com
Immune cells undergo dramatic metabolic reprogramming in response to external stimuli.
These metabolic pathways, long considered as simple housekeeping functions, are …

Immunotherapy strategies and prospects for acute lung injury: Focus on immune cells and cytokines

W Zhu, Y Zhang, Y Wang - Frontiers in Pharmacology, 2022 - frontiersin.org
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a disastrous condition,
which can be caused by a wide range of diseases, such as pneumonia, sepsis, traumas …

Metabolic adaptation of lymphocytes in immunity and disease

NM Chapman, H Chi - Immunity, 2022 - cell.com
Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Frontline Science: Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst

I Grondman, RJW Arts, RM Koch… - Journal of Leukocyte …, 2019 - academic.oup.com
Secondary infections are a major complication of sepsis and associated with a compromised
immune state, called sepsis-induced immunoparalysis. Molecular mechanisms causing …

Driving immunity: all roads lead to metabolism

EJ Pearce, EL Pearce - Nature Reviews Immunology, 2018 - nature.com
In 2017, studies of cellular metabolism broadly permeated immunological research.
Accumulating data support the view that understanding how metabolism regulates immune …