Synergistic Activity of Remdesivir–Nirmatrelvir Combination on a SARS-CoV-2 In Vitro Model and a Case Report

A Gidari, S Sabbatini, E Schiaroli, S Bastianelli… - Viruses, 2023 - mdpi.com
Background: This study aims to investigate the activity of the remdesivir–nirmatrelvir
combination against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and …

Remdesivir and GS-441524 retain antiviral activity against Delta, Omicron, and other emergent SARS-CoV-2 variants

J Pitts, J Li, JK Perry, V Du Pont, N Riola… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Genetic variation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
resulted in the emergence and rapid spread of multiple variants throughout the pandemic, of …

[HTML][HTML] First-generation oral antivirals against SARS-CoV-2

P Sendi, RR Razonable, SB Nelson, A Soriano… - Clinical Microbiology …, 2022 - Elsevier
Background Oral drugs against severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) have received emergency use authorization for the treatment of mild-to-moderate …

Real-world effectiveness of molnupiravir and nirmatrelvir/ritonavir as treatments for COVID-19 in patients at high risk

D Paraskevis, M Gkova, K Mellou… - The Journal of …, 2023 - academic.oup.com
Background Using a retrospective cohort study design, we aimed to evaluate the
effectiveness of molnupiravir and nirmatrelvir/ritonavir in patients with SARS-CoV-2 who …

Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients

JF Standing, L Buggiotti, JA Guerra-Assuncao… - Nature …, 2024 - nature.com
Viral clearance, antibody response and the mutagenic effect of molnupiravir has not been
elucidated in at-risk populations. Non-hospitalised participants within 5 days of SARS-CoV-2 …

Nirmatrelvir resistance—de novo E166V/L50V mutations in an immunocompromised patient treated with prolonged nirmatrelvir/ritonavir monotherapy leading to …

NS Zuckerman, E Bucris… - Clinical Infectious …, 2024 - academic.oup.com
Resistance of SARS-CoV-2 to antivirals was shown to develop in immunocompromised
individuals receiving remdesivir. We describe an immunocompromised patient who was …

[HTML][HTML] Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model

K Rosenke, A Okumura, MC Lewis, F Feldmann… - JCI insight, 2022 - ncbi.nlm.nih.gov
The recent emergence of the SARS-CoV-2 Omicron variant of concern (VOC), which
contains a heavily mutated spike protein capable of escaping preexisting immunity …

[HTML][HTML] Effect of oral nirmatrelvir on long COVID symptoms: 4 cases and rationale for systematic studies

MJ Peluso, K Anglin, MS Durstenfeld… - Pathogens and …, 2022 - ncbi.nlm.nih.gov
Background: Efforts to understand the impact of SARS-CoV-2 variants, vaccine status, and
treatment on the development and persistence of Long COVID have intensified. Methods …

The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition

MD Sacco, Y Hu, MV Gongora, F Meilleur, MT Kemp… - Cell research, 2022 - nature.com
Dear Editor, The ongoing SARS-CoV-2 pandemic continues to be a significant threat to
global health. First reported in November 2021, the Omicron variant (B. 1.1. 529) is more …

Comparative efficacy and safety of nirmatrelvir/ritonavir and molnupiravir for COVID‐19: A systematic review and meta‐analysis

B Amani, A Akbarzadeh, B Amani… - Journal of Medical …, 2023 - Wiley Online Library
This study aimed to compare the efficacy and safety of nirmatrelvir/ritonavir (Paxlovid) with
molnupiravir in the treatment of coronavirus disease 2019 (COVID‐19). To end this …