Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology
Background The release of neutrophil extracellular traps (NETs) is associated with
inflammation, coagulopathy, and organ damage found in severe cases of COVID-19 …
inflammation, coagulopathy, and organ damage found in severe cases of COVID-19 …
Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients
Y Zhang, K Han, C Du, R Li, J Liu, H Zeng, L Zhu, A Li - Critical Care, 2021 - Springer
Background Thrombosis and coagulopathy are highly prevalent in critically ill patients with
COVID-19 and increase the risk of death. Immunothrombosis has recently been …
COVID-19 and increase the risk of death. Immunothrombosis has recently been …
CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS
M Blot, M Jacquier, LS Aho Glele, G Beltramo… - Critical Care, 2020 - Springer
Background COVID-19-related ARDS has unique features when compared with ARDS from
other origins, suggesting a distinctive inflammatory pathogenesis. Data regarding the host …
other origins, suggesting a distinctive inflammatory pathogenesis. Data regarding the host …
Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury
Y Jiao, T Zhang, C Zhang, H Ji, X Tong, R Xia, W Wang… - Critical Care, 2021 - Springer
Abstract Background Polymorphonuclear neutrophils (PMNs) play an important role in
sepsis-related acute lung injury (ALI). Accumulating evidence suggests PMN-derived …
sepsis-related acute lung injury (ALI). Accumulating evidence suggests PMN-derived …
Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis
T Pan, S Sun, Y Chen, R Tian, E Chen, R Tan, X Wang… - Critical Care, 2022 - Springer
Background Effective removal of pathogenic bacteria is key to improving the prognosis of
sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate …
sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate …
Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China
Abstract Background Coronavirus disease 2019 (COVID-19) is a newly emerging infectious
disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome …
disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome …
Markers of endothelial and epithelial pulmonary injury in mechanically ventilated COVID-19 ICU patients
S Spadaro, A Fogagnolo, G Campo, O Zucchetti… - Critical care, 2021 - Springer
Background Biomarkers can be used to detect the presence of endothelial and/or alveolar
epithelial injuries in case of ARDS. Angiopoietin-2 (Ang-2), soluble intercellular adhesion …
epithelial injuries in case of ARDS. Angiopoietin-2 (Ang-2), soluble intercellular adhesion …
Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS
JA Lorente, N Nin, P Villa, D Vasco, AB Miguel-Coello… - Critical Care, 2021 - Springer
Background Acute respiratory distress syndrome (ARDS) is a type of respiratory failure
characterized by lung inflammation and pulmonary edema. Coronavirus disease 2019 …
characterized by lung inflammation and pulmonary edema. Coronavirus disease 2019 …
Staphylococcus aureus ventilator-associated pneumonia in patients with COVID-19: clinical features and potential inference with lung dysbiosis
Background Hospitalized patients with COVID-19 admitted to the intensive care unit (ICU)
and requiring mechanical ventilation are at risk of ventilator-associated bacterial infections …
and requiring mechanical ventilation are at risk of ventilator-associated bacterial infections …
Protective reactive thymus hyperplasia in COVID-19 acute respiratory distress syndrome
P Cuvelier, H Roux, A Couëdel-Courteille, J Dutrieux… - Critical Care, 2021 - Springer
Abstract Background Patients with COVID-19 (COVID) may develop acute respiratory
distress syndrome with or without sepsis, coagulopathy and visceral damage. While chest …
distress syndrome with or without sepsis, coagulopathy and visceral damage. While chest …