Spatial transcriptomics and proteomics provide complementary information that
independently transformed our understanding of complex biological processes. However …

The formation and maintenance of tissue integrity requires complex, coordinated activities
by thousands of genes and their encoded products. Until recently, transcript levels could …

Background Spatially-resolved transcriptomics has now enabled the quantification of high-
throughput and transcriptome-wide gene expression in intact tissue while also retaining the …

Emerging spatial profiling technology has enabled high-plex molecular profiling in biological
tissues, preserving the spatial and morphological context of gene expression. Here, we …

Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …

Recent spatial gene expression technologies enable comprehensive measurement of
transcriptomic profiles while retaining spatial context. However, existing analysis methods …

Considerable progress in sequencing technologies makes it now possible to study the
genomic and transcriptomic landscape of single cells. However, to better understand the …

Spatial transcriptomics is a rapidly growing field that promises to comprehensively
characterize tissue organization and architecture at the single-cell or subcellular resolution …

Spatial transcriptomic and proteomic technologies have provided new opportunities to
investigate cells in their native microenvironment. Here we present Giotto, a comprehensive …

As single-cell omics continue to advance, the field of spatially resolved transcriptomics has
emerged with a set of experimental and computational methods to map out the positions of …