Physiologically based pharmacokinetic (PBPK) models are increasingly used by drug
developers to evaluate the effect of patient factors on drug exposure. Between June 2008 …

Physiologically based pharmacokinetic (PBPK) modeling and simulation is a tool that can
help predict the pharmacokinetics of drugs in humans and evaluate the effects of intrinsic …

The purpose of this review was to assess the advancement of applications for
physiologically based pharmacokinetic (PBPK) modeling in various therapeutic areas. We …

The application of physiologically based pharmacokinetic (PBPK) modeling has developed
rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery …

Several regulatory guidances on the use of physiologically based pharmacokinetic (PBPK)
analyses and physiologically based biopharmaceutics model (s)(PBBM (s)) have been …

The aim of this tutorial is to introduce the concept of physiologically based pharmacokinetic
(PBPK) modeling to individuals in the pharmaceutical industry who may be relatively new to …

Modeling and simulation of drug disposition has emerged as an important tool in drug
development, clinical study design and regulatory review, and the number of physiologically …

During regulatory review of clinical pharmacology data in new drug applications and
biologics license applications, questions are routinely asked about how intrinsic factors (eg …

Since 2016, results from physiologically based pharmacokinetic (PBPK) analyses have
been routinely found in the clinical pharmacology section of regulatory applications …

We assess the advancement of physiologically based pharmacokinetic (PBPK) modeling
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …