Commitment to specific cell lineages is critical for mammalian embryonic development.
Lineage determination, differentiation, maintenance, and organogenesis result in diverse life …

Stem cell maturation is a fundamental, yet poorly understood aspect of human development.
We devised a DNA methylation signature deeply reminiscent of embryonic stem cells (a fetal …

Advances in single-cell genomics enable commensurate improvements in methods for
uncovering lineage relations among individual cells. Current sequencing-based methods for …

Natural and induced somatic mutations that accumulate in the genome during development
record the phylogenetic relationships of cells; whether these lineage barcodes capture the …

Tracing cell lineages is fundamental for understanding the rules governing development in
multicellular organisms and delineating complex biological processes involving the …

In mammals, all somatic development originates from lineage segregation in early embryos.
However, the dynamics of transcriptomes and epigenomes acting in concert with initial cell …

Lineage tracing and fate mapping, overlapping yet distinct disciplines to follow cells and
their progeny, have evolved rapidly over the last century. Lineage tracing aims to identify all …

Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …

Differences in chromatin organization are key to the multiplicity of cell states that arise from a
single genetic background, yet the landscapes of in vivo tissues remain largely uncharted …

Adult organisms rely on tissue stem cells for maintenance and repair. During homeostasis,
the concerted action of local niche signals and epigenetic regulators establish stable gene …