Brain organoids are 3D self-assembled structures composed of hundreds of thousands to
millions of cells that resemble the cellular organization and transcriptional and epigenetic …

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development,
thus offering an innovative tool by which to model human neurodevelopmental disease. We …

Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …

Scientists have been fascinated by the human brain for centuries, yet knowledge of the
cellular and molecular events that build the human brain during embryogenesis and of how …

Brain organoids are self‐organized, three‐dimensional (3D) aggregates derived from
pluripotent stem cells that have cell types and cellular architectures resembling those of the …

Neurological disorders are challenging to study given the complexity and species-specific
features of the organ system. Brain organoids are three dimensional structured aggregates …

Brain organoids are an exciting new technology with the potential to significantly change
how diseases of the brain are understood and treated. These three‐dimensional neural …

Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Simple Summary This review article describes an overview of the developed advanced
neural in vitro systems and the discovery of brain organoids including the recently …