REGEN-COV Antibody Combination in Outpatients With COVID-19–Phase 1/2 Results

T Norton, S Ali, S Sivapalasingam, H Gao, R Bhore… - medRxiv, 2021 - medrxiv.org
ABSTRACT Background Continued SARS-CoV-2 infections and COVID-19-related
hospitalizations highlight the need for effective anti-viral treatments in the outpatient setting …

REGEN-COV antibody cocktail clinical outcomes study in Covid-19 outpatients

DM Weinreich, S Sivapalasingam, T Norton, S Ali… - MedRxiv, 2021 - medrxiv.org
Background REGEN-COV antibody cocktail (casirivimab with imdevimab) rapidly reduced
viral load and decreased medically-attended visits in the phase 1/2 portion of this trial; …

REGEN-COV antibody combination and outcomes in outpatients with Covid-19

DM Weinreich, S Sivapalasingam… - … England Journal of …, 2021 - Mass Medical Soc
Background In the phase 1–2 portion of an adaptive trial, REGEN-COV, a combination of the
monoclonal antibodies casirivimab and imdevimab, reduced the viral load and number of …

REGN-COV2, a neutralizing antibody cocktail, in outpatients with Covid-19

DM Weinreich, S Sivapalasingam… - … England Journal of …, 2021 - Mass Medical Soc
Background Recent data suggest that complications and death from coronavirus disease
2019 (Covid-19) may be related to high viral loads. Methods In this ongoing, double-blind …

Phase 2 dose-ranging study of the virologic efficacy and safety of the combination COVID-19 antibodies casirivimab and imdevimab in the outpatient setting

C Portal-Celhay, E Forleo-Neto, W Eagan, BJ Musser… - medRxiv, 2021 - medrxiv.org
Background The monoclonal antibody combination casirivimab and imdevimab (REGEN-
COV®) reduced viral load, hospitalisation, or death when administered 1: 1 as an …

The clinical effectiveness of REGEN-COV in SARS-CoV-2 infection with Omicron versus Delta variants

HB Gershengorn, S Patel, T Ferreira, S Das, DJ Parekh… - Plos one, 2022 - journals.plos.org
Background In vitro studies suggesting that REGEN-COV (casirivimab plus imdevimab
monoclonal antibodies) had poor efficacy against Omicron-variant SARS-CoV-2 infection …

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

RECOVERY Collaborative Group, PW Horby… - Medrxiv, 2021 - medrxiv.org
Background REGEN-COV is a combination of 2 monoclonal antibodies (casirivimab and
imdevimab) that bind to two different sites on the receptor binding domain of the SARS-CoV …

[HTML][HTML] Subcutaneous REGEN-COV antibody combination in early asymptomatic SARS-Cov-2 infection: a randomized clinical trial

MP O'Brien, E Forleo-Neto, N Sarkar, F Isa, P Hou… - MedRxiv, 2021 - ncbi.nlm.nih.gov
Objective: Evaluate the efficacy and safety of subcutaneous casirivimab and imdevimab
antibody combination (REGEN-COV) to prevent progression from early asymptomatic SARS …

Subcutaneous REGEN-COV antibody combination to prevent Covid-19

MP O'Brien, E Forleo-Neto, BJ Musser… - … England Journal of …, 2021 - Mass Medical Soc
Background REGEN-COV (previously known as REGN-COV2), a combination of the
monoclonal antibodies casirivimab and imdevimab, has been shown to markedly reduce the …

Efficacy and safety of regdanvimab (CT-P59): a phase 2/3 randomized, double-blind, placebo-controlled trial in outpatients with mild-to-moderate coronavirus disease …

A Streinu-Cercel, O Săndulescu… - Open forum …, 2022 - academic.oup.com
Abstract Background Regdanvimab (CT-P59) is a monoclonal antibody with neutralizing
activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report …