Background: According to WHO, lower respiratory tract infections (LRTI) are the deadliest
communicable disease globally, causing 3.2 million deaths annually. Culture is the gold …

Lower respiratory infections (LRIs) accounted for three million deaths worldwide in 2016, the
leading infectious cause of mortality. The “gold standard” for investigation of bacterial LRIs is …

Objectives Lower respiratory tract infections (LRTIs) are one of the causes of mortality
among infectious diseases. Microbial cultures commonly used in clinical practice are time …

Respiratory tract infection (RTI) remains a significant cause of morbidity and mortality across
the globe. The optimal management of RTI relies upon timely pathogen identification via …

The gold standard for clinical diagnosis of bacterial lower respiratory infections (LRIs) is
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial …

Background Diversified etiology of lower respiratory tract infection renders diagnosis
challenging. The mainstay microbial culture is time-consuming and constrained by variable …

Background It is common to obtain a low detection rate and unsatisfactory detection results
in complex infection or rare pathogen detection. This retrospective study aimed to illustrate …

Background Nanopore metagenomics has been used for infectious disease diagnosis for
bacterial pathogens. However, this technology currently lacks comprehensive performance …

The rapid and effective identification of pathogens in patients with pulmonary infections has
posed a persistent challenge in medicine, with conventional microbiological tests (CMTs) …

Background Enzyme-based host depletion significantly improves the sensitivity of clinical
metagenomics. Recent studies found that real-time adaptive sequencing of DNA molecules …