In these studies, we examined the neuroprotective effects of the potent antiinflammatory
cytokine interleukin-10 (IL-10) following spinal cord injury (SCI). Neuroprotection was …

Intraspinal injection of quisqualic acid (QUIS) produces excitotoxic injury with pathological
characteristics similar to those associated with ischemic and traumatic spinal cord injury …

We have previously reported that the anti-inflammatory cytokine IL-10 induces a number of
signaling cascades through the IL-10 receptor in spinal cord neurons in vitro to activate NF …

Spinal cord injury (SCI) is a devastating condition affecting 270,000 people in the United
States. A potential treatment for decreasing the secondary inflammation, excitotoxic damage …

Abstract Interleukin‐10 (IL‐10) exerts a wide spectrum of regulatory activities in the immune
and inflammatory response. The aim of this study was to investigate the role of endogenous …

Background The anti-inflammatory cytokine interleukin-10 (IL-10) has been explored
previously as a treatment method for spinal cord injury (SCI) due to its ability to attenuate pro …

Background Recent in vivo and in vitro studies in non-neuronal and neuronal tissues have
shown that different pathways of macrophage activation result in cells with different …

Intraspinal injection of quisqualic acid (QUIS) produces excitotoxic injury with
pathophysiological characteristics similar to those associated with ischemic and traumatic …

Traumatic injury to the central nervous system initiates inflammatory processes that are
implicated in secondary tissue damage. These processes include the synthesis of …

A rapid proinflammatory response after peripheral nerve injury is required for clearance of
tissue debris (Wallerian degeneration) and effective regeneration. Unlike the CNS, this …