[HTML][HTML] Revisiting the roles of pro-metastatic EpCAM in cancer

MA Mohtar, SE Syafruddin, SN Nasir, TY Low - Biomolecules, 2020 - mdpi.com
Epithelial cell adhesion molecule (EpCAM) is a cell surface protein that was discovered as a
tumour marker of epithelial origins nearly four decades ago. EpCAM is expressed at basal …

[HTML][HTML] Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?

O Gires, M Pan, H Schinke, M Canis… - Cancer and Metastasis …, 2020 - Springer
EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …

EpCAM in carcinogenesis: the good, the bad or the ugly

BTF van der Gun, LJ Melchers, MHJ Ruiters… - …, 2010 - academic.oup.com
The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that is highly
expressed on most carcinomas and therefore of potential use as a diagnostic and prognostic …

[HTML][HTML] Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside

Y Liu, Y Wang, S Sun, Z Chen, S Xiang, Z Ding… - … hematology & oncology, 2022 - Springer
Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but
also participates in the development and progression of cancer. In recent decades …

[HTML][HTML] Current view on EpCAM structural biology

A Gaber, B Lenarčič, M Pavšič - Cells, 2020 - mdpi.com
EpCAM, a carcinoma cell-surface marker protein and a therapeutic target, has been
primarily addressed as a cell adhesion molecule. With regard to recent discoveries of its role …

[HTML][HTML] Biology and clinical relevance of EpCAM

L Keller, S Werner, K Pantel - Cell stress, 2019 - ncbi.nlm.nih.gov
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily
known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM expression …

The emerging role of EpCAM in cancer and stem cell signaling

M Munz, PA Baeuerle, O Gires - Cancer research, 2009 - AACR
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion
molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface …

EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis

G Spizzo, D Fong, M Wurm, C Ensinger… - Journal of clinical …, 2011 - jcp.bmj.com
Aims Epithelial cell adhesion molecule (EpCAM) is a cell surface protein with oncogenic
features that is expressed on healthy human epithelia and corresponding malignant …

EpCAM and its potential role in tumor-initiating cells

S Imrich, M Hachmeister, O Gires - Cell adhesion & migration, 2012 - Taylor & Francis
Epithelial cell adhesion molecule EpCAM is expressed on a subset of normal epithelia and
overexpressed on malignant cells from a variety of different tumor entities. This …

[HTML][HTML] EpCAM: structure and function in health and disease

U Schnell, V Cirulli, BNG Giepmans - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
Injection of tumor cells in mice more than 30years ago resulted in the discovery of an
epithelial antigen, later defined as a cell adhesion molecule (EpCAM). Although EpCAM has …