Canonical and noncanonical regulatory roles for JAK2 in the pathogenesis of rheumatoid arthritis‐associated interstitial lung disease and idiopathic pulmonary …
S Wang, M Liu, X Li, J Zhang, F Wang… - The FASEB …, 2022 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) and rheumatoid arthritis‐associated interstitial lung
disease (RA‐ILD) are two fibrotic interstitial lung diseases that share the usual interstitial …
disease (RA‐ILD) are two fibrotic interstitial lung diseases that share the usual interstitial …
The JAK2 pathway is activated in idiopathic pulmonary fibrosis
J Milara, G Hernandez, B Ballester, A Morell, I Roger… - Respiratory …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal
fibrotic disorder, with no curative therapies. The signal transducer and activator of …
fibrotic disorder, with no curative therapies. The signal transducer and activator of …
JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study
J Milara, B Ballester, A Morell, JL Ortiz, J Escrivá… - Thorax, 2018 - thorax.bmj.com
Background Pulmonary hypertension (PH) is a common disorder in patients with idiopathic
pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators …
pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators …
Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease
Y Kim, HI Yang, KS Kim - International Journal of Molecular Sciences, 2023 - mdpi.com
Interstitial lung disease (ILD) is one of the most serious extra-articular complications of
rheumatoid arthritis (RA), which increases the mortality of RA. Because the pathogenesis of …
rheumatoid arthritis (RA), which increases the mortality of RA. Because the pathogenesis of …
Role of JAK/STAT in interstitial lung diseases; molecular and cellular mechanisms
P Montero, J Milara, I Roger, J Cortijo - International journal of molecular …, 2021 - mdpi.com
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …
Two sides of the same coin? A review of the similarities and differences between idiopathic pulmonary fibrosis and rheumatoid arthritis-associated interstitial lung …
S Matson, J Lee, O Eickelberg - European Respiratory Journal, 2021 - Eur Respiratory Soc
Rheumatoid arthritis associated interstitial lung disease (RA-ILD) and idiopathic pulmonary
fibrosis (IPF) are distinct diseases; however, they share several clinical, radiographic and …
fibrosis (IPF) are distinct diseases; however, they share several clinical, radiographic and …
Therapeutic potential of janus kinase inhibitors for the management of interstitial lung disease
R Huo, Q Guo, J Hu, N Li, R Gao, L Mi… - Drug design …, 2023 - Taylor & Francis
Interstitial lung disease (ILD) refers to a heterogeneous group of diseases characterized by
lung fibroblast proliferation, interstitial inflammation, and fibrosis-induced lung damage. The …
lung fibroblast proliferation, interstitial inflammation, and fibrosis-induced lung damage. The …
Rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis: shared mechanistic and phenotypic traits suggest overlapping disease …
F Paulin, TJ Doyle, EA Fletcher… - Revista de …, 2015 - medigraphic.com
The prevalence of clinically evident interstitial lung disease in patients with rheumatoid
arthritis is approximately 10%. An additional 33% of undiagnosed patients have interstitial …
arthritis is approximately 10%. An additional 33% of undiagnosed patients have interstitial …
Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: perspectives for scleroderma-associated interstitial lung …
A Lescoat, M Lelong, M Jeljeli, C Piquet-Pellorce… - Biochemical …, 2020 - Elsevier
Janus kinase (JAK) inhibitors (also termed Jakinibs) constitute a family of small drugs that
target various isoforms of JAKs (JAK1, JAK2, JAK3 and/or tyrosine kinase 2 (Tyk2)). They …
target various isoforms of JAKs (JAK1, JAK2, JAK3 and/or tyrosine kinase 2 (Tyk2)). They …
Reinterpreting evidence of rheumatoid arthritis-associated interstitial lung disease to understand etiology
EK Wu, RD Ambrosini, RM Kottmann… - Current …, 2019 - ingentaconnect.com
Interstitial Lung Disease (ILD) is a well-known complication of rheumatoid arthritis (RA)
which often results in significant morbidity and mortality. It is often diagnosed late in the …
which often results in significant morbidity and mortality. It is often diagnosed late in the …