[HTML][HTML] Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release

LL Wu, Y Fan, S Li, XJ Li, XF Zhou - Journal of Biological Chemistry, 2010 - ASBMB
Brain-derived neurotrophic factor (BDNF) plays a pivotal role in brain development and
synaptic plasticity. It is synthesized as a precursor (pro-BDNF), sorted into the secretory …

Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism

D del Toro, JM Canals, S Ginés, M Kojima… - Journal of …, 2006 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) polymorphism is associated with the
pathophysiology of several neurodegenerative disorders, including Huntington's disease. In …

[HTML][HTML] Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF …

M Yang, Y Lim, X Li, JH Zhong, XF Zhou - Journal of Biological Chemistry, 2011 - ASBMB
proBDNF, a precursor of brain-derived neurotrophic factor (BDNF), is anterogradely
transported and released from nerve terminals, but the mechanism underlying this process …

Brain‐derived neurotrophic factor over‐expression in the forebrain ameliorates Huntington's disease phenotypes in mice

K Gharami, Y Xie, JJ An, S Tonegawa… - Journal of …, 2008 - Wiley Online Library
Abstract Huntington's disease (HD), a dominantly inherited neurodegenerative disorder
characterized by relatively selective degeneration of striatal neurons, is caused by an …

[HTML][HTML] Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

LR Gauthier, BC Charrin, M Borrell-Pagès… - Cell, 2004 - cell.com
Polyglutamine expansion (polyQ) in the protein huntingtin is pathogenic and responsible for
the neuronal toxicity associated with Huntington's disease (HD). Although wild-type …

Mutant huntingtin impairs BDNF release from astrocytes by disrupting conversion of Rab3a-GTP into Rab3a-GDP

Y Hong, T Zhao, XJ Li, S Li - Journal of Neuroscience, 2016 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is essential for neuronal differentiation and
survival. We know that BDNF levels decline in the brains of patients with Huntington's …

Co‐localization of brain‐derived neurotrophic factor (BDNF) and wild‐type huntingtin in normal and quinolinic acid‐lesioned rat brain

FR Fusco, C Zuccato, M Tartari… - European journal of …, 2003 - Wiley Online Library
Loss of huntingtin‐mediated brain‐derived neurotrophic factor (BDNF) gene transcription
has been described in Huntington's disease (HD)[Zuccato et al.(2001) Science, 293, 493 …

[HTML][HTML] Cortical axonal secretion of bdnf in the striatum is disrupted in the mutant-huntingtin knock-in mouse model of Huntington's disease

H Park - Experimental neurobiology, 2018 - ncbi.nlm.nih.gov
Deficient BDNF signaling is known to be involved in neurodegenerative diseases such as
Huntington's disease (HD). Mutant huntingtin (mhtt)-mediated disruption of either BDNF …

Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF

L Wang, F Lin, J Wang, J Wu, R Han, L Zhu, M DiFiglia… - Brain research, 2012 - Elsevier
Huntington's disease (HD) is an inheritable neurological disorder caused by an abnormal
expansion of the polyglutamine tract in the N-terminus of the protein huntingtin (htt). Mutant …

Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's …

JM Canals, JR Pineda, JF Torres-Peraza… - Journal of …, 2004 - Soc Neuroscience
The mechanism that controls the selective vulnerability of striatal neurons in Huntington's
disease is unclear. Brain-derived neurotrophic factor (BDNF) protects striatal neurons and is …