Action potential counting at giant mossy fiber terminals gates information transfer in the hippocampus

S Chamberland, Y Timofeeva… - Proceedings of the …, 2018 - National Acad Sciences
Neuronal communication relies on action potential discharge, with the frequency and the
temporal precision of action potentials encoding information. Hippocampal mossy fibers …

Main determinants of presynaptic Ca2+ dynamics at individual mossy fiber–CA3 pyramidal cell synapses

R Scott, DA Rusakov - Journal of Neuroscience, 2006 - Soc Neuroscience
Synaptic transmission between hippocampal mossy fibers (MFs) and CA3 pyramidal cells
exhibits remarkable use-dependent plasticity. The underlying presynaptic mechanisms …

Timing and efficacy of Ca2+ channel activation in hippocampal mossy fiber boutons

J Bischofberger, JRP Geiger, P Jonas - Journal of Neuroscience, 2002 - Soc Neuroscience
The presynaptic Ca2+ signal is a key determinant of transmitter release at chemical
synapses. In cortical synaptic terminals, however, little is known about the kinetic properties …

Action potential initiation and propagation in hippocampal mossy fibre axons

C Schmidt‐Hieber, P Jonas… - The Journal of …, 2008 - Wiley Online Library
Dentate gyrus granule cells transmit action potentials (APs) along their unmyelinated mossy
fibre axons to the CA3 region. Although the initiation and propagation of APs are …

Interplay between synchronization of multivesicular release and recruitment of additional release sites support short-term facilitation at hippocampal mossy fiber to …

S Chamberland, A Evstratova, K Tóth - Journal of Neuroscience, 2014 - Soc Neuroscience
Synaptic short-term plasticity is a key regulator of neuronal communication and is controlled
via various mechanisms. A well established property of mossy fiber to CA3 pyramidal cell …

Short-term facilitation at a detonator synapse requires the distinct contribution of multiple types of voltage-gated calcium channels

S Chamberland, A Evstratova, K Tóth - Journal of Neuroscience, 2017 - Soc Neuroscience
Neuronal calcium elevations are shaped by several key parameters, including the
properties, density, and the spatial location of voltage-gated calcium channels (VGCCs) …

Glutamate imaging reveals multiple sites of stochastic release in the CA3 giant mossy fiber boutons

S Rama, TP Jensen, DA Rusakov - Frontiers in Cellular …, 2019 - frontiersin.org
One of the most studied central synapses which have provided fundamental insights into
cellular mechanisms of neural connectivity is the “giant” excitatory connection between …

Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network

J Bischofberger, D Engel, M Frotscher, P Jonas - Pflügers Archiv, 2006 - Springer
It is widely accepted that the hippocampus plays a major role in learning and memory. The
mossy fiber synapse between granule cells in the dentate gyrus and pyramidal neurons in …

Dynamic control of presynaptic Ca2+ inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons

JRP Geiger, P Jonas - Neuron, 2000 - cell.com
Abstract Analysis of presynaptic determinants of synaptic strength has been difficult at
cortical synapses, mainly due to the lack of direct access to presynaptic elements. Here we …

Slow‐decaying presynaptic calcium dynamics gate long‐lasting asynchronous release at the hippocampal mossy fiber to CA3 pyramidal cell synapse

S Chamberland, Y Timofeeva, A Evstratova… - Synapse, 2020 - Wiley Online Library
Action potentials trigger two modes of neurotransmitter release, with a fast synchronous
component and a temporally delayed asynchronous release. Asynchronous release …