Reconstruction of bone defects by tissue engineered substitutes requires coordinated
coupling between osteogenesis and angiogenesis. Basic fibroblast growth factor (bFGF or …

Large segmental bone defect repair remains a clinical and scientific challenge with
increasing interest focused on combining gene transfer with tissue engineering techniques …

The successful clinical outcome of the implanted tissue-engineered bone is dependent on
the establishment of a functional vascular network. A gene-enhanced tissue engineering …

Large segmental bone defect repair remains a challenge in orthopedic surgeries. The tissue
engineered bone graft will be a promising approach if vascularization of the graft is realized …

Regulation of transgene expression and function is important for gene therapy because it
allows complex biological processes to be controlled and monitored. Basic fibroblast growth …

Engineering a large vascularized bone graft is a much greater challenge than engineering
small bone tissues. Although this is essentially feasible through an osteogenic factor-based …

A promising strategy for augmenting bone formation involves the local delivery of multiple
osteoinductive and vasculogenic growth factors. However, success depends on sustained …

Objective Bone regeneration involves a coordinated cascade of events that are regulated by
several cytokines and growth factors, among which bone morphogenic protein-2 (BMP-2) …

Bone is a highly vascularized tissue and efficient bone regeneration requires
neovascularization, especially for critical-sized bone defects. We developed a novel hybrid …

Regenerating bone tissue involves complex, temporal and coordinated signal cascades of
which bone morphogenic protein-2 (BMP-2) and vascular endothelial growth factor …