The pathogenesis of pulmonary fibrosis: a moving target

WA Wuyts, C Agostini, KM Antoniou… - European …, 2013 - Eur Respiratory Soc
Pulmonary fibrosis is the end stage of many diffuse parenchymal lung diseases. It is
characterised by excessive matrix formation leading to destruction of the normal lung …

New mechanisms of pulmonary fibrosis

RM Strieter, B Mehrad - Chest, 2009 - Elsevier
The understanding of the pathogenesis of pulmonary fibrosis continues to evolve. The initial
hypothetical model suggested chronic inflammation as the cause of pulmonary fibrosis …

Pulmonary fibrosis: cytokines in the balance

RK Coker, GJ Laurent - European Respiratory Journal, 1998 - Eur Respiratory Soc
Pulmonary fibrosis can complicate diverse pulmonary and systemic pathologies. In many
cases the underlying cause remains unidentified. Mortality from the disease is increasing …

Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?

TM Maher, AU Wells, GJ Laurent - European Respiratory …, 2007 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a devastating condition that carries a prognosis worse
than that of many cancers. A recent classification of the idiopathic interstitial pneumonias …

[HTML][HTML] Molecular and cellular mechanisms of pulmonary fibrosis

NW Todd, IG Luzina, SP Atamas - Fibrogenesis & tissue repair, 2012 - Springer
Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

Emerging concepts in the pathogenesis of lung fibrosis

WD Hardie, SW Glasser, JS Hagood - The American journal of pathology, 2009 - Elsevier
Fibrogenesis is an often-deadly process with increasing world-wide incidence and limited
therapeutic options. Pulmonary fibrogenesis involves remodeling of the distal airspace and …

Molecular mechanisms of and possible treatment strategies for idiopathic pulmonary fibrosis

M Gharaee-Kermani, SH Phan - Current pharmaceutical design, 2005 - ingentaconnect.com
Pulmonary fibrosis is characterized by lung inflammation and abnormal tissue repair,
resulting in the replacement of normal functional tissue with an abnormal accumulation of …

Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …

Novel therapeutic approaches for pulmonary fibrosis

A Datta, CJ Scotton… - British journal of …, 2011 - Wiley Online Library
Pulmonary fibrosis represents the end stage of a number of heterogeneous conditions and
is, to a greater or lesser degree, the hallmark of the interstitial lung diseases. It is …

Idiopathic pulmonary fibrosis: from epithelial injury to biomarkers-insights from the bench side

M Kolb, K Borensztajn, B Crestani, M Kolb - Respiration, 2014 - karger.com
Idiopathic pulmonary fibrosis (IPF) is the most frequent fibrotic diffuse parenchymal lung
disease. Its prognosis is devastating:> 50% of the patients die within 3 years after diagnosis …