Spectrum of fibrotic lung diseases

M Wijsenbeek, V Cottin - New England Journal of Medicine, 2020 - Mass Medical Soc
Pulmonary Fibrotic Diseases This review covers fibrotic pulmonary diseases. Although
idiopathic pulmonary fibrosis is very common, the review focuses mainly on fibrotic diseases …

Tissue remodelling in pulmonary fibrosis

L Knudsen, C Ruppert, M Ochs - Cell and tissue research, 2017 - Springer
Many lung diseases result in fibrotic remodelling. Fibrotic lung disorders can be divided into
diseases with known and unknown aetiology. Among those with unknown aetiology …

An official American Thoracic Society workshop report: use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis

RG Jenkins, BB Moore, RC Chambers… - American journal of …, 2017 - atsjournals.org
Numerous compounds have shown efficacy in limiting development of pulmonary fibrosis
using animal models, yet few of these compounds have replicated these beneficial effects in …

Growth factors in idiopathic pulmonary fibrosis: relative roles

JT Allen, MA Spiteri - Respiratory research, 2001 - Springer
Abstract Treatment of idiopathic pulmonary fibrosis patients has evolved very slowly; the
fundamental approach of corticosteroids alone or in combination with other …

New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis

IE Fernandez, O Eickelberg - The Lancet, 2012 - thelancet.com
Idiopathic pulmonary fibrosis is a serious and progressive chronic lung disease that is
characterised by altered cellular composition and homoeostasis in the peripheral lung …

Pathogenic mechanisms underlying idiopathic pulmonary fibrosis

BJ Moss, SW Ryter, IO Rosas - Annual Review of Pathology …, 2022 - annualreviews.org
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis

DN O'Dwyer, SL Ashley… - American Journal of …, 2016 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by
accumulation of extracellular matrix (ECM) and impaired gas exchange. The pathobiological …

Approaches to the treatment of pulmonary fibrosis.

GW Hunninghake, AR Kalica - American journal of respiratory and …, 1995 - atsjournals.org
There was a general consensus at the workshop that pulmonary fibrosis is a highly lethal
lung disorder and that current therapies for this disease have little effect on the natural …

[PDF][PDF] Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis

J May, JA Mitchell, RG Jenkins - Journal of Clinical …, 2023 - Am Soc Clin Investig
Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor
survival. The incidence and mortality of IPF are rising, but treatment remains limited …