Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis

PW Noble, RJ Homer - American journal of respiratory cell and …, 2005 - atsjournals.org
One of the more challenging areas of pulmonary medicine remains elucidating the
pathogenesis of idiopathic pulmonary fibrosis (IPF). IPF is a devastating disease process …

The role of immune and inflammatory cells in idiopathic pulmonary fibrosis

O Desai, J Winkler, M Minasyan, EL Herzog - Frontiers in medicine, 2018 - frontiersin.org
The contribution of the immune system to idiopathic pulmonary fibrosis (IPF) remains poorly
understood. While most sources agree that IPF does not result from a primary …

Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis

JA Kropski, WE Lawson, LR Young… - Disease models & …, 2013 - journals.biologists.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal lung disease for which
there is no known treatment. Although the traditional paradigm of IPF pathogenesis …

Molecular mechanisms of pulmonary fibrogenesis and its progression to lung cancer: a review

T Kinoshita, T Goto - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive
fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and …

Challenges for clinical drug development in pulmonary fibrosis

ES White, M Thomas, S Stowasser… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium.
Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a …

The pathogenesis of idiopathic pulmonary fibrosis

WR Coward, G Saini, G Jenkins - Therapeutic advances in …, 2010 - journals.sagepub.com
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an appalling
prognosis. The failure of anti-inflammatory therapies coupled with the observation that …

New perspectives on basic mechanisms in lung disease. 1. Lung injury, inflammatory mediators, and fibroblast activation in fibrosing alveolitis.

MN Sheppard, NK Harrison - Thorax, 1992 - thorax.bmj.com
It is over 25 years since Scadding first defined the term fibrosing alveolitis. It has since been
established that complex mechanisms underlie its pathogenesis, including epithelial and …

Non‐invasive biomarkers in pulmonary fibrosis

A Prasse, J MÜLLER‐QUERNHEIM - Respirology, 2009 - Wiley Online Library
The practise of modern medicine is unthinkable without biological markers, and their
adoption is now established in various clinical settings. Pulmonary fibrosis occurs in a …

Lung inflammation and fibrosis

PA Ward, GW Hunninghake - … journal of respiratory and critical care …, 1998 - atsjournals.org
Lung research supported by the National Heart, Lung, and Blood Institute (NHLBI) has had
important outcomes that have resulted in an infinitely better understanding of how …

The role of infection in the pathogenesis of idiopathic pulmonary fibrosis

PL Molyneaux, TM Maher - European Respiratory Review, 2013 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive, and invariably fatal, condition that is
believed to arise in genetically susceptible individuals as a consequence of an aberrant …