microRNAs as therapeutic targets in intestinal diseases

C Wang, J Chen - ExRNA, 2019 - Springer
Intestinal diseases, which primarily include inflammatory bowel disease (IBD), colorectal
cancer (CRC) and colitis associated cancer (CAC), are believed to develop as a result of …

miRNAs can affect intestinal epithelial barrier in inflammatory bowel disease

X Xiao, X Mao, D Chen, B Yu, J He, H Yan… - Frontiers in …, 2022 - frontiersin.org
The most obvious pathological characterization of inflammatory bowel disease (IBD) is
intestinal epithelium erosion and severe inflammation invasion. Micro-ribonucleic acids …

Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis

J Lee, EJ Park, Y Yuki, S Ahmad, K Mizuguchi… - Scientific reports, 2015 - nature.com
Inflammatory bowel diseases (IBDs) accompany a critical loss of the frontline barrier function
that is achieved primarily by intestinal epithelial cells (IECs). Although the gene-regulation …

Functional role and therapeutic targeting of microRNAs in inflammatory bowel disease

A Soroosh, M Koutsioumpa… - American Journal …, 2018 - journals.physiology.org
Inflammatory bowel diseases (IBD) are chronic inflammatory gastrointestinal diseases,
primarily consisting of ulcerative colitis and Crohn's disease. The complex nature of the …

Whole blood profiling of T-cell-derived microRNA allows the development of prognostic models in inflammatory bowel disease

R Kalla, AT Adams, NT Ventham… - Journal of Crohn's …, 2020 - academic.oup.com
Background MicroRNAs [miRNAs] are cell-specific small non-coding RNAs that can regulate
gene expression and have been implicated in inflammatory bowel disease [IBD] …

MiRNA-based therapies for the treatment of inflammatory bowel disease: what are we still missing?

T Innocenti, E Bigagli, EN Lynch, A Galli… - Inflammatory Bowel …, 2023 - academic.oup.com
Micro-RNAs (miRNAs) are noncoding RNAs usually 24-30 nucleotides long that play a
central role in epigenetic mechanisms of inflammatory diseases and cancers. Recently …

The impact of microRNAs during inflammatory bowel disease: effects on the mucus layer and intercellular junctions for gut permeability

S Stiegeler, K Mercurio, MA Iancu, SC Corr - Cells, 2021 - mdpi.com
Research on inflammatory bowel disease (IBD) has produced mounting evidence for the
modulation of microRNAs (miRNAs) during pathogenesis. MiRNAs are small, non-coding …

Differential expression of microRNAs in peripheral blood mononuclear cells identifies autophagy and TGF-beta-related signatures aberrantly expressed in …

A Mohammadi, OB Kelly, M Filice… - Journal of Crohn's …, 2018 - academic.oup.com
Abstract Background and Aims MicroRNAs [miRNAs] have emerged as important regulators
in inflammatory bowel disease [IBD]. This study investigated differential expression of …

Altered mucosal expression of microRNAs in pediatric patients with inflammatory bowel disease

NJ Béres, Z Kiss, Z Sztupinszki, G Lendvai… - Digestive and Liver …, 2017 - Elsevier
Introduction MicroRNAs (miRs) came recently into focus as promising novel research targets
offering new insights into the pathogenesis of inflammatory bowel diseases (IBD). Aims The …

[HTML][HTML] MicroRNAs expression influence in ulcerative colitis and Crohn's disease: A pilot study for the identification of diagnostic biomarkers

AEV Quaglio, FJ Santaella… - World journal of …, 2021 - ncbi.nlm.nih.gov
BACKGROUND Inflammatory bowel disease (IBD) comprises two distinct diseases, Crohn's
disease (CD) and ulcerative colitis (UC), both of which are chronic, relapsing inflammatory …