Nucleic acids are regarded as reliable biomarkers for the early diagnosis of various
diseases. By ingeniously combining a transduction hairpin (THP) with the toehold-mediated …

We demonstrate for the first time the construction of a low background electrochemical
biosensor with tandem signal amplification for sensitive microRNA assay based on target …

An efficient and innovative strategy for colorimetric detection of bisphenol A (BPA) is shown
here based on target-induced catalytic hairpin assembly (CHA) and DNAzyme-caused …

The DNA microarray has distinctive advantages of high-throughput and less complicated
operations, but tends to have a relatively low sensitivity. Catalytic hairpin assembly (CHA) is …

Kinetically trapped hairpin DNA has great potential to dynamically build nanostructures,
which can be initiated by sequence-specific nucleic acids. The branched junction, which has …

Tumor cells in blood circulation (CTCs) are vital biomarkers for noninvasive cancer
diagnosis. We developed a simple and sensitive electrochemical biosensor based on dual …

Nucleic acids can be programmed into enzyme-free catalytic DNA circuits (CDCs) to carry
out various functions ranging from DNA computing to signal amplifications for biosensing …

Engineered nucleic acid hairpin structures are used for the amplified analysis of low-
molecular-weight substrates (adenosine monophosphate, AMP) or proteins (lysozyme). The …

Simultaneous detection of various intracellular biomarkers is promising for early diagnosis
and treatment of cancer. Herein, a split primer ligation-triggered catalyzed hairpin assembly …

Herein, a sensitive photoelectrochemical-electrochemical (PEC-EC) dual-mode biosensor
with opposite readout signals was constructed for sensitive and accurate detection of miRNA …