Idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung
disease (SSc-ILD) differ in the predominant demographics and identified genetic risk alleles …

There are currently few treatment options for pulmonary fibrosis. Innovations may come from
a better understanding of the cellular origin of the characteristic fibrotic lesions. We have …

Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ
failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive …

Objectives Myofibroblasts are key effector cells in the extracellular matrix remodelling of
systemic sclerosis-associated interstitial lung disease (SSc-ILD); however, the diversity of …

The loss of normal alveolar capillary and deregulated angiogenesis occurs simultaneously
in idiopathic pulmonary fibrosis (IPF); however the contributions of specific endothelial …

Metabolic reprogramming has been intrinsically linked to macrophage activation. Alveolar
macrophages are known to play an important role in the pathogenesis of pulmonary fibrosis …

Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic disease of the distal
lung alveoli that culminates in respiratory failure and reduced lifespan. Unlike normal lung …

Pulmonary fibrosis (PF) is a growing clinical problem which can result in breathlessness or
respiratory failure and has an average life expectancy of 3 years from diagnosis …

The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model …

Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by
the histopathological pattern of usual interstitial pneumonia and is associated with a high …