Background and Purpose—Cerebral small-vessel disease and cerebral blood flow (CBF)
are interrelated. However, the direction of the relationship is unknown, and longitudinal …

Cerebral small vessel disease (SVD) contributes to 25% of ischemic strokes and 45% of
dementias. We aimed to investigate the role of cerebral blood flow (CBF) and intracranial …

White matter hyperintensities are frequent on neuroimaging of older people and are a key
feature of cerebral small vessel disease. They are commonly attributed to chronic …

Background Cerebral white matter hyperintensities (WMHs), lacunes, and microbleeds are
seen on magnetic resonance imaging (MRI) in small vessel disease (SVD). Purpose To …

Cerebral small vessel disease (SVD) is a major contributor to stroke and dementia,
characterized by white matter hyperintensities (WMH) on neuroimaging. WMH are …

Background Low cerebral blood flow (CBF) has been associated with the presence of white
matter lesions (WMLs). However, the power of these studies was insufficient (n= 20–35) to …

Background and Purpose—Increased blood–brain barrier (BBB) permeability occurs in
cerebral small vessel disease. It is not known if BBB changes predate progression of small …

Cerebral small vessel disease (CSVD) is a common finding on brain magnetic resonance
imaging (MRI). We previously demonstrated that high blood pressure (BP) and low carotid …

Background Cerebral small vessel disease (cSVD) is a late consequence of cerebral
microvascular dysfunction (MVD). MVD is hard to measure in the brain due to its limited …

Knowledge about the longitudinal change of cerebral small-vessel disease–related
magnetic resonance imaging abnormalities increases our pathophysiologic understanding …