Promotion of osteogenesis in tissue‐engineered bone by pre‐seeding endothelial progenitor cells‐derived endothelial cells

H Yu, PJ VandeVord, W Gong, B Wu… - Journal of …, 2008 - Wiley Online Library
In addition to a biocompatible scaffold and an osteogenic cell population, tissue‐engineered
bone requires an appropriate vascular bed to overcome the obstacle of nutrient and oxygen …

The role of endothelial progenitor cells in prevascularized bone tissue engineering: development of heterogeneous constructs

NE Fedorovich, RT Haverslag, WJA Dhert… - … Engineering Part A, 2010 - liebertpub.com
In vitro prevascularization of bone grafts with endothelial progenitor cells (EPCs) is a
promising strategy to improveimplant survival. In this study we show bone formation in …

Improved tissue-engineered bone regeneration by endothelial cell mediated vascularization

H Yu, PJ VandeVord, L Mao, HW Matthew, PH Wooley… - Biomaterials, 2009 - Elsevier
Natural bone growth greatly depends on the precedent vascular network that supplies
oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue …

Composite implantation of mesenchymal stem cells with endothelial progenitor cells enhances tissue‐engineered bone formation

K Usami, H Mizuno, K Okada, Y Narita… - … Research Part A: An …, 2009 - Wiley Online Library
For successful tissue engineering, neovascularization of the implanted tissue is critical.
Factors generated by endothelial cells are also considered crucial for the process of …

Engineering vascularized bone graft with osteogenic and angiogenic lineage differentiated bone marrow mesenchymal stem cells

R Zhang, Z Gao, W Geng, X Yan, F Chen… - Artificial organs, 2012 - Wiley Online Library
Tissue‐engineered bone provides a promising method for the rehabilitation of acquired
bone defects and congenital deformities. However, generating a vascular supply to the …

Biocompatibility of Poly-ε-caprolactone-hydroxyapatite composite on mouse bone marrow-derived osteoblasts and endothelial cells

H Yu, PH Wooley, SY Yang - Journal of Orthopaedic Surgery and …, 2009 - Springer
Background Tissue-engineered bone may be developed by seeding the cells capable of
both osteogenesis and vascularization on biocompatible composite scaffolds. The current …

Differentiation of rabbit bone mesenchymal stem cells into endothelial cells in vitro and promotion of defective bone regeneration in vivo

J Liu, C Liu, B Sun, C Shi, C Qiao, X Ke, S Liu… - Cell Biochemistry and …, 2014 - Springer
Tissue engineering strategies often fail to regenerate bones because of inadequate
vascularization, especially in the reconstruction of large segmental bone defects. Large …

Enhanced bone tissue regeneration of a biomimetic cellular scaffold with co‐cultured MSCs‐derived osteogenic and angiogenic cells

L Li, J Li, Q Zou, Y Zuo, B Cai, Y Li - Cell proliferation, 2019 - Wiley Online Library
Objectives The bone tissue engineering primarily focuses on three‐dimensional co‐culture
systems, which physical and biological properties resemble the cell matrix of actual tissues …

Differential analysis of peripheral blood‐and bone marrow‐derived endothelial progenitor cells for enhanced vascularization in bone tissue engineering

AR Amini, CT Laurencin… - Journal of orthopaedic …, 2012 - Wiley Online Library
For tissue engineering applications, effective bone regeneration requires rapid neo‐
vascularization of implanted grafts to ensure the survival of cells in the early post …

Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct

J Rouwkema, JD Boer, CAV Blitterswijk - Tissue engineering, 2006 - liebertpub.com
To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …