ABSTRACT A comprehensive analysis and characterization of a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …

The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled
testing of vaccines and therapeutics and defining aspects of severe acute respiratory …

The emergence of SARS-CoV-2 has created an international health crisis, and small animal
models mirroring SARS-CoV-2 human disease are essential for medical countermeasure …

SARS-CoV-2 emerged in late 2019 and resulted in the ongoing COVID-19 pandemic.
Several animal models have been rapidly developed that recapitulate the asymptomatic to …

Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread
throughout the world, resulting in a global public health emergency. The lack of vaccine and …

Murine models of SARS-CoV-2 infection are critical for elucidating the biological pathways
underlying COVID-19. Because human angiotensin-converting enzyme 2 (ACE2) is the …

COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We
previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV …

The development of animal models for COVID-19 is essential for basic research and
drug/vaccine screening. Previously reported COVID-19 animal models need to be …

Although animal models have been evaluated for severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease …

COVID-19 is the most consequential pandemic of the 21st century. Since the earliest stage
of the 2019-2020 epidemic, animal models have been useful in understanding the …