IgA dominates the early neutralizing antibody response to SARS-CoV-2

D Sterlin, A Mathian, M Miyara, A Mohr… - Science translational …, 2021 - science.org
Humoral immune responses are typically characterized by primary IgM antibody responses
followed by secondary antibody responses associated with immune memory and composed …

Enhanced SARS-CoV-2 neutralization by dimeric IgA

Z Wang, JCC Lorenzi, F Muecksch, S Finkin… - Science translational …, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes
coronavirus disease 2019 (COVID-19), primarily infects cells at mucosal surfaces. Serum …

SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

J Wu, B Liang, C Chen, H Wang, Y Fang… - Nature …, 2021 - nature.com
Long-term antibody responses and neutralizing activities in response to SARS-CoV-2
infection are not yet clear. Here we quantify immunoglobulin M (IgM) and G (IgG) antibodies …

Distinct features and functions of systemic and mucosal humoral immunity among SARS-CoV-2 convalescent individuals

SE Butler, AR Crowley, H Natarajan, S Xu… - Frontiers in …, 2021 - frontiersin.org
Understanding humoral immune responses to SARS-CoV-2 infection will play a critical role
in the development of vaccines and antibody-based interventions. We report systemic and …

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

B Isho, KT Abe, M Zuo, AJ Jamal, B Rathod… - Science …, 2020 - science.org
While the antibody response to SARS-CoV-2 has been extensively studied in blood,
relatively little is known about the antibody response in saliva and its relationship to systemic …

Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent …

S Sheikh-Mohamed, B Isho, GYC Chao, M Zuo… - Mucosal …, 2022 - nature.com
Although SARS-CoV-2 infects the upper respiratory tract, we know little about the amount,
type, and kinetics of antibodies (Ab) generated in the oral cavity in response to COVID-19 …

[PDF][PDF] Rapid decline of neutralizing antibodies is associated with decay of IgM in adults recovered from mild COVID-19

WE Harrington, O Trakhimets, DV Andrade… - Cell Reports …, 2021 - cell.com
The fate of protective immunity following mild severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2) infection remains ill defined. Here, we characterize antibody …

Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19

C Cervia, J Nilsson, Y Zurbuchen, A Valaperti… - Journal of Allergy and …, 2021 - Elsevier
Background Whereas severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-
specific antibody tests are increasingly being used to estimate the prevalence of SARS-CoV …

Longitudinal systemic and mucosal immune responses to SARS-CoV-2 infection

PF Wright, AC Prevost-Reilly… - The Journal of …, 2022 - academic.oup.com
Background A longitudinal study was performed to determine the breadth, kinetics, and
correlations of systemic and mucosal antibody responses to severe acute respiratory …

[HTML][HTML] SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

F Liew, S Talwar, A Cross, BJ Willett, S Scott… - …, 2023 - thelancet.com
Background Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving
limited insights into mucosal defences that prevent viral replication and onward …