The influenza A RNA polymerase possesses endonuclease activity to digest the host mRNA.
Thus this endonuclease domain can be a target of anti-influenza A virus drug. Here we …

The influenza RNA polymerase complex, which consists of the three subunits PA, PB1, and
PB2, is a promising target for the development of new antiviral drugs. A large library of …

Since 2003, highly pathogenic H5N1 influenza viruses have been the cause of large-scale
death in poultry and the subsequent infection and death of over 140 humans. At present …

In continuing our efforts to identify small molecules able to disrupt the interaction of the
polymerase acidic protein–basic protein 1 (PA–PB1) subunits of influenza virus (Flu) RNA …

The PA protein of Influenza A virus (IAV) encoded by segment 3 acts as a specialized RNA
endonuclease in the transcription of the viral genome. The same genomic segment encodes …

In the search for new anti-influenza agents, the viral polymerase has often been targeted
due to the involvement of multiple conserved proteins and their distinct activities …

Influenza polymerase (FluPol) plays a key role in the viral infection cycle by transcribing and
replicating the viral genome. FluPol is a multifunctional, heterotrimeric enzyme with cap …

The PA subunit of the influenza virus polymerase complex is a phosphorylated protein that
induces a proteolytic process that decreases its own accumulation levels and those of …

The influenza virus PA endonuclease is an attractive target for the development of novel anti-
influenza virus therapeutics, which are urgently needed because of the emergence of drug …

The influenza virus RNA-dependent RNA polymerase is highly conserved among influenza
A, B, C, and D viruses. It comprises three subunits: polymerase basic protein 1 (PB1) …