Immunotherapy of COVID-19: inside and beyond IL-6 signalling

G Zizzo, A Tamburello, L Castelnovo, A Laria… - Frontiers in …, 2022 - frontiersin.org
Acting on the cytokine cascade is key to preventing disease progression and death in
hospitalised patients with COVID-19. Among anti-cytokine therapies, interleukin (IL)-6 …

The immune system as a target for therapy of SARS-CoV-2: a systematic review of the current immunotherapies for COVID-19

AH Mansourabadi, M Sadeghalvad… - Life sciences, 2020 - Elsevier
Aims The immune response is essential for the control and resolution of viral infections.
Following the outbreak of novel coronavirus disease (COVID-19), several immunotherapies …

[HTML][HTML] Severe COVID-19: what have we learned with the immunopathogenesis?

B Bordallo, M Bellas, AF Cortez, M Vieira… - Advances in …, 2020 - SciELO Brasil
The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has become a global major concern. In this review, we addressed a theoretical …

Interleukin-1 in COVID-19 Infection: Immunopathogenesis and Possible Therapeutic Perspective

A Mardi, S Meidaninikjeh, S Nikfarjam… - Viral …, 2021 - liebertpub.com
The newfound coronavirus disease 2019 (COVID-19), initiated by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is an international public health concern …

COVID-19: risk for cytokine targeting in chronic inflammatory diseases?

G Schett, M Sticherling, MF Neurath - Nature Reviews Immunology, 2020 - nature.com
COVID-19, caused by the SARS-CoV-2 virus, has become pandemic. With sharply rising
infection rates, patient groups characterized by an enhanced infection risk will be …

Thoughts on COVID-19 and autoimmune diseases

AD Askanase, L Khalili, JP Buyon - Lupus Science & Medicine, 2020 - lupus.bmj.com
Over the 2 months since coronavirus first appeared in China, cases have emerged on every
continent, and it is clear that patients with autoimmune diseases might also be affected …

Immunopathology and immunotherapeutic strategies in severe acute respiratory syndrome coronavirus 2 infection

S Keam, D Megawati, SK Patel, R Tiwari… - Reviews in Medical …, 2020 - Wiley Online Library
The outbreak of coronavirus disease 2019 (COVID‐19) and pandemic, caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has become a major concern …

COVID-19: inflammatory profile

Y Wang, S Perlman - Annual review of medicine, 2022 - annualreviews.org
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has resulted in a pandemic that has had widespread …

Is IL-6 a key cytokine target for therapy in COVID-19?

SA Jones, CA Hunter - Nature Reviews Immunology, 2021 - nature.com
The identification of elevated IL-6 levels in patients with severe COVID-19 led to the rapid
development of clinical trials targeting this cytokine. Overall, these trials do not support the …

The intersection of COVID-19 and autoimmunity

JS Knight, R Caricchio, JL Casanova… - The Journal of …, 2021 - Am Soc Clin Investig
Acute COVID-19, caused by SARS-CoV-2, is characterized by diverse clinical presentations,
ranging from asymptomatic infection to fatal respiratory failure, and often associated with …