Over the past 50 years, like molecular cell biology, medicine and pharmacology have been
driven by a reductionist approach. The focus on individual genes and cellular components …

High‐throughput experimental techniques for generating genomes, transcriptomes,
proteomes, metabolomes, and interactomes have provided unprecedented opportunities to …

Systems biology is an integrative discipline connecting the molecular components within a
single biological scale and also among different scales (eg cells, tissues and organ systems) …

Despite the promises made that genomic sequencing would transform therapy by
introducing a new era of personalized medicine, relatively few tangible breakthroughs have …

Systems biology aims to provide a holistic and in many cases dynamic picture of biological
function and malfunction, in case of disease. Technology developments in the generation of …

Failure to achieve efficacy is among the top, if not the most common reason for clinical trial
failures. While there may be many underlying contributors to these failures, selecting the …

Systems medicine is an interdisciplinary approach that integrates data from basic research
and clinical practice to improve our understanding and treatment of diseases. Systems …

The conventional way of characterizing a disease consists of correlating clinical symptoms
with pathological findings. Although this approach for many years has assisted clinicians in …

Systems biology is in an exponential development stage in recent years and has been
widely utilized in biomedicine to better understand the molecular basis of human disease …

The complexity of human biology makes it challenging to develop safe and effective new
medicines. Systems biology omics-based efforts have led to an explosion of high-throughput …