Therapeutic implications of the immunoscore in patients with colorectal cancer

C El Sissy, A Kirilovsky, G Zeitoun, F Marliot… - Cancers, 2021 - mdpi.com
Simple Summary Beyond the TNM-staging system, biomarkers are needed to guide cancer
treatments. We provide an overview of the Immunoscore, a standardized immune assay …

Immunoscore assay for the immune classification of solid tumors: Technical aspects, improvements and clinical perspectives

F Marliot, L Lafontaine, J Galon - Methods in Enzymology, 2020 - Elsevier
The past two decades witnessed the appreciation of the importance of specific tumor-
infiltrating immune cells in influencing tumor evolution. The discovery that a favorable …

[HTML][HTML] Analytical validation of the Immunoscore and its associated prognostic value in patients with colon cancer

F Marliot, X Chen, A Kirilovsky, T Sbarrato… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background New and fully validated tests need to be brought into clinical practice to improve
the estimation of recurrence risk in patients with colon cancer. The aim of this study was to …

Validation of the Immunoscore (IM) as a prognostic marker in stage I/II/III colon cancer: Results of a worldwide consortium-based analysis of 1,336 patients.

J Galon, B Mlecnik, F Marliot, FS Ou, CB Bifulco… - 2016 - ascopubs.org
3500 Background: Mounting evidence indicates an enhanced lymphocytic reaction as an
informative prognostic indicator in colon cancer (CC). The IM methodology has been defined …

Immunoscore®: A Diagnostic Assay for Clinical Management of Colon Cancer

HA Blair - Molecular Diagnosis & Therapy, 2020 - Springer
Immunoscore® is an in vitro diagnostic assay that is designed to predict the risk of relapse in
patients with early-stage colon cancer, thus helping to guide treatment strategies …

Usefulness and robustness of Immunoscore for personalized management of cancer patients

F Marliot, F Pagès, J Galon - Oncoimmunology, 2020 - Taylor & Francis
This review details the analytical performance characteristics of the consensus
Immunoscore, measuring the immune response to cancer, improving the estimation of risk of …

The immunoscore: colon cancer and beyond

HK Angell, D Bruni, JC Barrett, R Herbst, J Galon - Clinical cancer research, 2020 - AACR
Tumors evolve in close interaction with their microenvironment, which encompasses a
continual tension between the developing tumor and the host immune system. Clinical trials …

Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients

A Kirilovsky, F Marliot, C El Sissy… - International …, 2016 - academic.oup.com
Abstract The American Joint Committee on Cancer/Union Internationale Contre le Cancer
(AJCC/UICC) tumor, nodes, metastasis (TNM) classification system based on tumor features …

Principles of risk assessment in colon cancer: immunity is key

A Hijazi, J Galon - Oncoimmunology, 2024 - Taylor & Francis
In clinical practice, the administration of adjuvant chemotherapy (ACT) following tumor
surgical resection raises a critical dilemma for stage II colon cancer (CC) patients. The …

Multicenter international study of the consensus immunoscore for the prediction of relapse and survival in early-stage colon cancer

B Mlecnik, A Lugli, G Bindea, F Marliot, C Bifulco… - Cancers, 2023 - mdpi.com
Simple Summary This work determines the predictive value of the consensus Immunoscore
in 1885 patients with AJCC/UICC-TNM stage I-II Colon Cancer (CC) from North American …