Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …

Given the heterogeneity of senescent cells, our knowledge of both the drivers and
consequences of cellular senescence in tissues and organs remains limited, as is our …

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance,
and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …

Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …

Cellular senescence is defined as irreversible cell cycle arrest caused by various processes
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …

Cellular senescence is a highly complex and programmed cellular state with diverse and, at
times, conflicting physiological and pathological roles across the lifespan of an organism …

Cellular senescence is characterized as a stable proliferation arrest that can be triggered by
multiple stresses. Most knowledge about senescent cells is obtained from studies in primary …

The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …