Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

Cellular senescence is a major driver of age-related diseases, and senotherapies are being
tested in clinical trials. Despite its popularity, cellular senescence is weakly defined and is …

Chronological age represents the single greatest risk factor for human disease. One
plausible explanation for this correlation is that mechanisms that drive ageing might also …

Cellular senescence is a state of irreversible cellular growth arrest accompanied by distinct
changes in gene expression and the acquisition of a complex proinflammatory secretory …

Introduction Cellular senescence is a rapidly growing field with potential relevance for the
treatment of multiple human diseases. In the last decade, cellular senescence and the …

Life expectancy has drastically increased over the last few decades worldwide, with
important social and medical burdens and costs. To stay healthy longer and to avoid chronic …

Cellular senescence is the final fate of most cells in response to specific stimuli, but is not the
end. Indeed, it is the beginning of a singular life, with multiple side roads leading to diverse …

Senescent cells play important roles in both physiological and pathological processes,
including cancer and aging. In all cases, however, senescent cells comprise only a small …

Cellular senescence is a major contributor to age-related diseases in humans; however, it
also has a beneficial role in physiological and pathological processes, including wound …

Cellular senescence is a state of stable cell cycle arrest arising in response to DNA and
mitochondrial damages. Senescent cells undergo morphological, structural and functional …