Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Senescence refers to a cellular state featuring a stable cell‐cycle arrest triggered in
response to stress. This response also involves other distinct morphological and intracellular …

Aging is the most important single risk factor for many chronic diseases such as cancer,
metabolic syndrome, and neurodegenerative disorders. Targeting aging itself might …

In response to cellular stress or damage, proliferating cells can induce a specific program
that initiates a state of long-term cell-cycle arrest, termed cellular senescence. Accumulation …

Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular
mechanisms, one of which is cellular senescence. The abundance of senescent cells in …

Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …

Cellular senescence correlates with changes in the transcriptome. To obtain a complete
view on senescence-associated transcription networks and pathways, we assessed by deep …

Cellular senescence, a permanent state of cell cycle arrest, is believed to have originally
evolved to limit the proliferation of old or damaged cells. However, it has been recently …