Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome …
Cellular senescence refers to a process induced by various types of stress that causes irreversible cell cycle arrest and distinct cellular alterations, including profound changes in …
Senescence is a state of permanent cell cycle arrest. Cellular senescence can promote tissue remodelling but can negatively affect regenerative capacities of tissues and contribute …
A Hernandez-Segura, S Brandenburg… - JoVE (Journal of …, 2018 - jove.com
Cellular senescence is a state of permanent cell cycle arrest activated in response to different damaging stimuli. Activation of cellular senescence is a hallmark of various …
M Ogrodnik - Aging cell, 2021 - Wiley Online Library
The field of research on cellular senescence experienced a rapid expansion from being primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …
Y Sun, JP Coppé, EWF Lam - Trends in Molecular Medicine, 2018 - cell.com
Cellular senescence is a process that results in irreversible cell-cycle arrest, and is thought to be an autonomous tumor-suppressor mechanism. During senescence, cells develop …
D McHugh, J Gil - Journal of Cell Biology, 2018 - rupress.org
Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. Although we are far from understanding the biological basis of …
E Sikora, A Bielak-Zmijewska, G Mosieniak - Ageing research reviews, 2021 - Elsevier
Cellular senescence is a stress response, which can be evoked in all type of somatic cells by different stimuli. Senescent cells accumulate in the body and participate in aging and …
T Yasuda, H Baba, T Ishimoto - The FEBS Journal, 2023 - Wiley Online Library
Cellular senescence in cancer development is known to have tumor‐suppressive and tumor‐ promoting roles. Recent studies have revealed numerous molecular mechanisms of …