Antiamoebic Activity of Imidazothiazole Derivatives against Opportunistic Pathogen Acanthamoeba castellanii

N Akbar, MI El-Gamal, BQ Saeed, CH Oh… - Antibiotics, 2022 - mdpi.com
We examined the antiamoebic effect of several imidazothiazole derivatives on
Acanthamoeba castellanii of the T4 genotype. Trypan blue exclusion assays and …

Azole-based compounds as potential anti-Acanthamoeba agents

BQ Saeed, R Hamdy, N Akbar, SE Sajeevan… - RSC Medicinal …, 2024 - pubs.rsc.org
Acanthamoeba castellanii is an opportunistic pathogen with public health implications,
largely due to its invasive nature and non-specific symptoms. Our study focuses on the …

Amoebicidal activity of benzothiazole on Acanthamoeba castellanii cysts and trophozoites and its cytotoxic potentials

N Ozpinar, H Ozpinar, BB Bakay, T Tunc - Acta tropica, 2020 - Elsevier
Acanthamoeba spp. are free-living amoebae isolated from many ecological areas such as
swimming pools, dams and lakes, and soil. Granulomatous amebic encephalitis and amebic …

[HTML][HTML] Isobenzofuran-1 (3H)-one derivatives: Amoebicidal activity and program cell death in Acanthamoeba castellanii Neff

RL Rodríguez-Expósito, M Reyes-Batlle… - Biomedicine & …, 2022 - Elsevier
The genus Acanthamoeba is characterized by being a group of ubiquitous and free-living
amoebae that inhabit a variety of environments. Generally, human infections by this parasite …

Anti-amoebic activity of a series of benzofuran/benzothiophene derivatives against Acanthamoeba castellanii belonging to the T4 genotype

N Akbar, MI El-Gamal, SO Zaraei… - Journal of Applied …, 2023 - academic.oup.com
Aims To determine the anti-amoebic activity of benzofuran/benzothiophene-possessing
compounds against Acanthamoeba castellanii of the T4 genotype. Method and results A …

Novel tetrazoles against Acanthamoeba castellanii belonging to the T4 genotype

YI Wehelie, NA Khan, I Fatima, A Anwar, K Kanwal… - Chemotherapy, 2022 - karger.com
Background: Acanthamoeba castellanii is a pathogenic free-living amoeba responsible for
blinding keratitis and fatal granulomatous amoebic encephalitis. However, treatments are …

Applications of medicinal chemistry for drug discovery against Acanthamoeba infections

U Ahmed, A Anwar, SK Ong, A Anwar… - Medicinal Research …, 2022 - Wiley Online Library
Acanthamoeba is a genus of free‐living amoebae, pervasively found in the environment.
Most of its pathogenic species are the causative agent of sight‐threatening Acanthamoeba …

Imidazothiazole derivatives exhibited potent effects against brain-eating amoebae

R Siddiqui, MI El-Gamal, A Boghossian, BQ Saeed… - Antibiotics, 2022 - mdpi.com
Naegleria fowleri (N. fowleri) is a free-living, unicellular, opportunistic protist responsible for
the fatal central nervous system infection, primary amoebic meningoencephalitis (PAM) …

The amoebicidal activity of three substances derived from benzothiazole on Acanthamoeba castellanii cysts and trophozoites and its cytotoxic potentials

N Ozpinar, G Culha, T Kaya, H Yucel - Acta Tropica, 2021 - Elsevier
Acanthamoeba species are free-living amoebae isolated from many ecological areas such
as swimming pools, dams, lakes, soil, and air filters. These amoebae are usually causing …

Recent progress on the discovery of antiamoebic agents

F Hayat, A Azam, D Shin - Bioorganic & Medicinal Chemistry Letters, 2016 - Elsevier
A large number of protozoans infect humans but Entamoeba histolytica is the only organism
responsible for causing amoebiasis, a deadly disease after malaria. Numerous heterocycle …