Chelation of intracellular zinc triggers apoptosis in mature thymocytes. - Abstract - Europe
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High concentrations of zinc salts (500 m̈M and greater) are known to inhibit apoptosis in a
variety of systems. However, closer examination of dose effects revealed that lower …

Zinc is a crucial nutritional component required for the normal development and
maintenance of immune functions. It has been reported that zinc is a potent inhibitor of DNA …

There is a great deal of interest in chemicals and biochemicals that can modulate apoptosis.
As will be discussed, zinc, an essential trace element, can induce as well as block …

Apoptosis—or programmed cell death—is an active type of cell death, occurring in several
pathophysiological conditions. One of the most important characteristics of apoptosis is that …

Abstract Changes in intracellular Ca 2+ concentration ([Ca 2+] i) are believed to have a
crucial role in triggering apoptosis, the process whereby cells are eliminated during tissue …

Alterations in intracellular Zn 2+ concentrations are believed to play a crucial role in
modulating apoptosis. The observation that Zn 2+ deficiency can induce cell death both in …

A23187, a calcium ionophore, is used to induce Ca2+-dependent cell death by increasing
intracellular Ca2+ concentration ([Ca2+] i) under in vitro condition. Since this ionophore also …

Abstract The endoplasmic reticular Ca 2+-ATPase inhibitor, thapsigargin, was used to study
the role of an increase in cytosolic free calcium concentration ([Ca 2+] i) as a signal for the …

Cadmium (Cd) is a well-known environmental carcinogen and immunotoxin. Currently the
direct cytotoxic effects of Cd on thymocytes are largely unexplored. The main objective of the …