Eupafolin inhibits PGE2 production and COX2 expression in LPS-stimulated human dermal fibroblasts by blocking JNK/AP-1 and Nox2/p47phox pathway

MH Tsai, ZC Lin, CJ Liang, FL Yen, YC Chiang… - Toxicology and applied …, 2014 - Elsevier
Eupafolin, a major active component found in the methanol extracts of Phyla nodiflora, has
been used to treat inflammation of skin. We examined its effects on cyclooxygenase-2 (COX …

Eupafolin ameliorates COX-2 expression and PGE2 production in particulate pollutants-exposed human keratinocytes through ROS/MAPKs pathways

CW Lee, ZC Lin, LF Hsu, JY Fang, YC Chiang… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Eupafolin is a major bioactive compound derived from the
methanolic extract of the medicinal herb Phyla nodiflora, which has been used in traditional …

[HTML][HTML] The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice

GF Passos, R Medeiros, R Marcon… - European journal of …, 2013 - Elsevier
Inflammation underlies the development and progression of a number of skin disorders
including psoriasis, atopic dermatitis and cancer. Therefore, novel antiinflammatory agents …

Peoniflorin suppresses tumor necrosis factor-α induced chemokine production in human dermal microvascular endothelial cells by blocking nuclear factor-κB and …

T Chen, Z Guo, X Jiao, R Jia, Y Zhang, J Li… - Archives of …, 2011 - Springer
Peoniflorin (PF) extracted from the root of Paeonia lactiflora pall displays anti-inflammation
and antioxidant properties in several animal models. Chemokines are vital for directing the …

The anti-inflammatory effects and mechanisms of eupafolin in lipopolysaccharide-induced inflammatory responses in RAW264. 7 macrophages

CC Chen, MW Lin, CJ Liang, SH Wang - PLoS One, 2016 - journals.plos.org
Eupafolin is a flavone isolated from Artemisia princeps Pampanini (family Asteraceae). The
aim of this study was to examine the anti-inflammatory effects of eupafolin in …

Anti‐inflammatory effect of pelubiprofen, 2‐[4‐(oxocyclohexylidenemethyl)‐phenyl] propionic acid, mediated by dual suppression of COX activity and LPS‐induced …

JS Shin, SR Baek, S Sohn, Y Cho… - Journal of cellular …, 2011 - Wiley Online Library
Pelubiprofen is a non‐steroidal anti‐inflammatory drugs (NSAIDs) that is related both
structurally and pharmacologically to ibuprofen. Anti‐inflammatory properties of ibuprofen …

Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways

S Qi, Y Xin, Y Guo, Y Diao, X Kou, L Luo… - International …, 2012 - Elsevier
Ampelopsin (AMP), a plant flavonoid, has potent anti-inflammatory properties in vitro and in
vivo. The molecular mechanisms of ampelopsin on pharmacological and biochemical …

The protective effect of eupafolin against TNF-α-induced lung inflammation via the reduction of intercellular cell adhesion molecule-1 expression

HC Sung, CJ Liang, CW Lee, FL Yen, CY Hsiao… - Journal of …, 2015 - Elsevier
Ethnopharmacological relevance Eupafolin, a major bioactive compound found in Phyla
nodiflora, has the anti-inflammatory property. Upregulation of cell adhesion molecules in the …

Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL‐1β‐induced PGE2 production in human skin fibroblasts

I Furuhashi, S Iwata, T Sato, H Inoue… - Journal of pharmacy …, 2005 - Wiley Online Library
Licochalcone A, a novel flavonoid isolated from the root of Glycyrrhiza inflata, has been
reported to exhibit anti‐inflammatory activity in animal models. In this study, we examined …

Patchoulene Epoxide Isolated from Patchouli Oil Suppresses Acute Inflammation through Inhibition of NF‐κB and Downregulation of COX‐2/iNOS

JL Liang, JZ Wu, YH Liu, ZB Zhang… - Mediators of …, 2017 - Wiley Online Library
According to the GC‐MS analysis, compositional variation was observed between samples
of patchouli oil, of which an unknown compound identified as patchoulene epoxide (PAO) …