When considering preclinical studies to evaluate the safety and immunogenicity of putative
vaccine candidates, such as nucleic acid vaccines, species most closely related to humans …

Nonhuman primates are suitable and valid models to determine the safety, immunogenicity
and efficacy of candidate vaccines that are being developed for human application. Among …

The nonhuman primates (NHPs) model in biomedical research has contributed to the study
of human infectious, autoimmune, oncogenic, and neurological diseases. This review …

Introduction: The search for a preventative HIV vaccine is ongoing after three decades of
research. Contributions of non-human primate (NHP) models to this research are irrefutable …

Non-human primates (NHPs) are used extensively in the development of vaccines and
therapeutics for human disease. High standards in the design, conduct, and reporting of …

Preclinical studies in nonhuman primates (NHP) play key roles in AIDS vaccine
development efforts. In addition to their traditional utilization to gauge vaccine safety and …

The demand for nonhuman primates will undoubtedly increase to meet biomedical needs in
this current age of biodefense. The availability of funding has increased the research on …

The development of human vaccines continues to rely on the use of animals for research.
Regulatory authorities require novel vaccine candidates to undergo preclinical assessment …

The pre-clinical efficacy of DNA vaccines has been demonstrated in a number of animal
models, but more limited data exist regarding their immunogenicity in non-human primates …

Animal models are an essential feature of the vaccine design toolkit. Although animal
models have been invaluable in delineating the mechanisms of immune function, their …