The genes encoding the aflatoxin biosynthetic pathway enzymes have been localized as a
cluster to a 75-kb DNA fragment. The enzymatic functions of the products of most of the …

An Aspergillus parasiticus gene, designated apa-2, was identified as a regulatory gene
associated with aflatoxin biosynthesis. The apa-2 gene was cloned on the basis of …

Aflatoxins belong to a family of decaketides that are produced as secondary metabolites by
Aspergillus flavus and A. parasiticus. The aflatoxin biosynthetic pathway involves several …

Aflatoxins are extremely potent carcinogens produced by Aspergillus flavus and Aspergillus
parasiticus. Cloning of genes in the aflatoxin pathway provides a specific approach to …

Affatoxins, a group of polyketide-derived furanocoumarins (Fig. 1), are the most toxic and
carcinogenic compounds among the known mycotoxins. Among the at least 16 structurally …

The Aspergillus parasiticus aflJ gene, which is located in the aflatoxin biosynthetic gene
cluster and is transcribed divergently from the aflatoxin pathway regulatory gene aflR …

A multiplex PCR reaction was developed to amplify the aflatoxin biosynthetic genes:
norsolorinic acid reductase (nor-1), versicolorin A dehydrogenase (ver-1) and …

Aflatoxins are secondary metabolites produced by Aspergillus flavus and Aspergillus
parasiticus. Most of the genes involved in the biosynthesis of aflatoxin are contained within a …

Until recently, only three species (Aspergillus flavus, A. parasiticus and A. nomius) have
been widely recognized as producers of aflatoxin. In this study we examine aflatoxin …

Aspergillus flavus mutant strain 649, which has a genomic DNA deletion of at least 120 kb
covering the aflatoxin biosynthesis cluster, was transformed with a series of overlapping …