Distinct phenotypic clusters of glioblastoma growth and response kinetics predict survival

CA Rayfield, F Grady, G De Leon, R Rockne… - JCO clinical cancer …, 2018 - ascopubs.org
Purpose Despite the intra-and intertumoral heterogeneity seen in glioblastoma multiforme
(GBM), there is little definitive data on the underlying cause of the differences in patient …

Prognostic significance of growth kinetics in newly diagnosed glioblastomas revealed by combining serial imaging with a novel biomathematical model

CH Wang, JK Rockhill, M Mrugala, DL Peacock, A Lai… - Cancer research, 2009 - AACR
Glioblastomas are the most aggressive primary brain tumors, characterized by their rapid
proliferation and diffuse infiltration of the brain tissue. Survival patterns in patients with …

Combining multimodal imaging and treatment features improves machine learning‐based prognostic assessment in patients with glioblastoma multiforme

JC Peeken, T Goldberg, T Pyka, M Bernhofer… - Cancer …, 2019 - Wiley Online Library
Background For Glioblastoma (GBM), various prognostic nomograms have been proposed.
This study aims to evaluate machine learning models to predict patients' overall survival …

Machine learning-based prediction of early recurrence in glioblastoma patients: a glance towards precision medicine

GM Della Pepa, VM Caccavella, G Menna, T Ius… - …, 2021 - journals.lww.com
BACKGROUND Ability to thrive and time-to-recurrence following treatment are important
parameters to assess in patients with glioblastoma multiforme (GBM), given its dismal …

A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram

SD Ferguson, TR Hodges, NK Majd… - Neuro-oncology …, 2021 - academic.oup.com
Background Glioblastoma (GBM) is the most common primary malignant brain tumor in
adulthood. Despite multimodality treatments, including maximal safe resection followed by …

Response classification based on a minimal model of glioblastoma growth is prognostic for clinical outcomes and distinguishes progression from pseudoprogression

ML Neal, AD Trister, S Ahn, A Baldock, CA Bridge… - Cancer research, 2013 - AACR
Glioblastoma multiforme is the most aggressive type of primary brain tumor. Glioblastoma
growth dynamics vary widely across patients, making it difficult to accurately gauge their …

[HTML][HTML] Rethinking glioma treatment strategy

T Ozawa, EC Holland - Oncotarget, 2014 - ncbi.nlm.nih.gov
Over the past decade, deep molecular analysis has revealed that many cancers, including
glioblastomas (GBMs), can be subdivided in several subtypes according to genetic and/or …

Identification of a panel of genes as a prognostic biomarker for glioblastoma

F Wang, Z Zheng, J Guan, D Qi, S Zhou, X Shen… - …, 2018 - thelancet.com
Background Glioblastoma multiforme (GBM) is a fatal disease without effective therapy.
Identification of new biomarkers for prognosis would enable more rational selections of …

Personalized prognosis stratification of newly diagnosed glioblastoma applying a statistical decision tree model

K Conrad, R Löber-Handwerker, M Hazaymeh… - Journal of Neuro …, 2024 - Springer
Purpose Glioblastoma (GBM) is the most frequent glioma in adults with a high treatment
resistance resulting into limited survival. The individual prognosis varies depending on …

Cluster-based prognostication in glioblastoma: Unveiling heterogeneity based on diffusion and perfusion similarities

M Foltyn-Dumitru, T Kessler, F Sahm, W Wick… - Neuro …, 2024 - academic.oup.com
Background While the association between diffusion and perfusion magnetic resonance
imaging (MRI) and survival in glioblastoma is established, prognostic models for patients are …