HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K …
KH Jung, MJ Choi, S Hong, H Lee, SW Hong… - Cancer letters, 2012 - Elsevier
The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in cell proliferation
and survival of human cancers. As PI3K is active in many cancer patients, resulting in cancer …
and survival of human cancers. As PI3K is active in many cancer patients, resulting in cancer …
IPD-196, a novel phosphatidylinositol 3-kinase inhibitor with potent anticancer activity against hepatocellular carcinoma
JH Lee, H Lee, SM Yun, KH Jung, Y Jeong, HH Yan… - Cancer letters, 2013 - Elsevier
As the activation of phosphatidylinositol 3-kinase (PI3K) is associated with a wide variety of
human malignancies, it is emerging as an attractive target for cancer treatment. In this study …
human malignancies, it is emerging as an attractive target for cancer treatment. In this study …
HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis
We synthesized a novel imidazopyridine analogue, a PI3Kα inhibitor HS-173 and
investigated anti-cancer capacity in human cancer cells. HS-173 inhibited the PI3K signaling …
investigated anti-cancer capacity in human cancer cells. HS-173 inhibited the PI3K signaling …
DHW-208, A novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-hepatocellular carcinoma activity through promoting apoptosis and inhibiting angiogenesis
S Wang, Y Wu, M Liu, Q Zhao, L Jian - Frontiers in Oncology, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide with high
prevalence and lethality. Due to insidious onset and lack of early symptoms, most HCC …
prevalence and lethality. Due to insidious onset and lack of early symptoms, most HCC …
Suppression of tumor proliferation and angiogenesis of hepatocellular carcinoma by HS-104, a novel phosphoinositide 3-kinase inhibitor
KH Jung, HM Zheng, Y Jeong, MJ Choi, H Lee… - Cancer letters, 2013 - Elsevier
Dysregulation of the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signaling pathway
frequently instigates tumorigenesis leading to hepatocellular carcinoma (HCC). We …
frequently instigates tumorigenesis leading to hepatocellular carcinoma (HCC). We …
DZW-310, a novel phosphoinositide 3-kinase inhibitor, attenuates the angiogenesis and growth of hepatocellular carcinoma cells via PI3K/AKT/mTOR axis
Y Wu, X Xu, M Liu, X Qin, Q Wu, H Ding… - Biochemical …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most malignant tumors worldwide with high
lethality and prevalence. The deregulated phosphoinositide 3-kinase/protein kinase …
lethality and prevalence. The deregulated phosphoinositide 3-kinase/protein kinase …
Anticancer activity of HS-527, a novel inhibitor targeting PI3-kinase in human pancreatic cancer cells
YL Ryu, KH Jung, MK Son, HH Yan, SJ Kim, S Shin… - Cancer Letters, 2014 - Elsevier
Pancreatic cancer is known to have low 5-year survival rate and poor response to treatment.
In this study, we synthesized HS-527, a new PI3-kinase inhibitor, and investigated not only …
In this study, we synthesized HS-527, a new PI3-kinase inhibitor, and investigated not only …
A novel imidazopyridine derivative, HS-106, induces apoptosis of breast cancer cells and represses angiogenesis by targeting the PI3K/mTOR pathway
Abnormal activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway is an essential
step for the formation and growth of tumors in humans. HS-106 is an imidazopyridine …
step for the formation and growth of tumors in humans. HS-106 is an imidazopyridine …
Discovery of new azaindole-based PI3Kα inhibitors: Apoptotic and antiangiogenic effect on cancer cells
Phosphatidylinositol-3-kinase alpha (PI3Kα) is an important target in cancer due to the
deregulation of the PI3K/AKT signaling pathway in many tumors. In this study, we designed …
deregulation of the PI3K/AKT signaling pathway in many tumors. In this study, we designed …
Novel 4-aminoquinazoline derivatives induce growth inhibition, cell cycle arrest and apoptosis via PI3Kα inhibition
YH Fan, HW Ding, DD Liu, HR Song, YN Xu… - Bioorganic & Medicinal …, 2018 - Elsevier
Abstract Phosphatidylinositol 3-kinase (PI3K) signaling pathway has diverse functions,
including the regulation of cellular survival, proliferation, cell cycle, migration, angiogenesis …
including the regulation of cellular survival, proliferation, cell cycle, migration, angiogenesis …