Exosome as a novel shuttle for delivery of therapeutics across biological barriers

CK Das, BC Jena, I Banerjee, S Das… - Molecular …, 2018 - ACS Publications
The effective delivery of target-specific siRNA to the brain by exploiting the exosomes
derived from dendritic cells renders the paradigm shift for the prospective use of nanosized …

Exosome-based drug delivery: translation from bench to clinic

HB Koh, HJ Kim, SW Kang, TH Yoo - Pharmaceutics, 2023 - mdpi.com
Exosome-based drug delivery is emerging as a promising field with the potential to
revolutionize therapeutic interventions. Exosomes, which are small extracellular vesicles …

Exosomes as naturally occurring vehicles for delivery of biopharmaceuticals: insights from drug delivery to clinical perspectives

A Butreddy, N Kommineni, N Dudhipala - Nanomaterials, 2021 - mdpi.com
Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics
owing to their natural origin, their ability to mediate intercellular communication, and their …

Exosomes as new generation vehicles for drug delivery: biomedical applications and future perspectives

A Rajput, A Varshney, R Bajaj, V Pokharkar - Molecules, 2022 - mdpi.com
Currently, particular interest among the scientific community is focused on exploring the use
of exosomes for several pharmaceutical and biomedical applications. This is due to the …

Development and regulation of exosome‐based therapy products

EV Batrakova, MS Kim - Wiley Interdisciplinary Reviews …, 2016 - Wiley Online Library
Recently, various innovative therapies involving the ex vivo manipulation and subsequent
reintroduction of exosome‐based therapeutics into humans have been developed and …

Exosomes as natural nanocarrier-based drug delivery system: recent insights and future perspectives

S Sen, J Xavier, N Kumar, MZ Ahmad, OP Ranjan - 3 Biotech, 2023 - Springer
Abstract Exosomes are nanosized (size~ 30–150 nm) natural vesicular structures released
from cells by physiological processes or pathological circumstances. Exosomes are growing …

Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new …

S Lakhal, MJA Wood - Bioessays, 2011 - Wiley Online Library
The demonstration that dendritic cell (DC)‐derived exosomes can be exploited for targeted
RNAi delivery to the brain after systemic injection provides the first proof‐of‐concept for the …

The therapeutic potential and clinical significance of exosomes as carriers of drug delivery system

T Li, X Li, G Han, M Liang, Z Yang, C Zhang, S Huang… - Pharmaceutics, 2022 - mdpi.com
Drug delivery system (DDS) realizes the drug delivery process through the drug carrier. As
an important part of DDS, the selection of the drug carrier material is extremely critical, which …

Challenges in the development and establishment of exosome-based drug delivery systems

J Wang, D Chen, EA Ho - Journal of Controlled Release, 2021 - Elsevier
Exosomes are extracellular vesicles released from cells and are characterized by a lipid
bilayer membrane encapsulating a variety of biological molecules such as nucleic acids or …

Exosomes as drug delivery systems: A brief overview and progress update

SM Patil, SS Sawant, NK Kunda - European Journal of Pharmaceutics and …, 2020 - Elsevier
Exosomes are intracellular membrane-based vesicles with diverse compositions that are
involved in biological and pathological processes. Since the discovery of exosomes, they …