SARS-CoV-2: repurposed drugs and novel therapeutic approaches—insights into chemical structure—biological activity and toxicological screening

CA Dehelean, V Lazureanu, D Coricovac… - Journal of clinical …, 2020 - mdpi.com
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic represents the
primary public health concern nowadays, and great efforts are made worldwide for efficient …

Pharmacological insight into potential therapeutic agents for the deadly Covid-19 pandemic

R Bhandari, G Khanna, A Kuhad - European Journal of Pharmacology, 2021 - Elsevier
Coronaviruses are pleomorphic, enveloped, or spherical viruses, which have a size ranging
from 80 to 120 nm. These viruses act on receptors that cause the triggering of fusion …

An update on antiviral therapy against SARS-CoV-2: how far have we come?

O Indari, S Jakhmola, E Manivannan… - Frontiers in …, 2021 - frontiersin.org
COVID-19 pandemic has spread worldwide at an exponential rate affecting millions of
people instantaneously. Currently, various drugs are under investigation to treat an …

An overview on anti-COVID-19 drug achievements and challenges ahead

M Valipour, H Irannejad, H Keyvani - ACS Pharmacology & …, 2023 - ACS Publications
The appearance of several coronavirus pandemics/epidemics during the last two decades
(SARS-CoV-1 in 2002, MERS-CoV in 2012, and SARS-CoV-2 in 2019) indicates that …

Current scenario and future prospect in the management of COVID-19

P Borah, PK Deb, S Deka… - Current Medicinal …, 2021 - ingentaconnect.com
The COVID-19 pandemic continues to wreak havoc worldwide due to the lack of risk
assessment, rapid spreading ability, and propensity to precipitate severe disease in …

The rationale for potential pharmacotherapy of COVID-19

M Saber-Ayad, MA Saleh, E Abu-Gharbieh - Pharmaceuticals, 2020 - mdpi.com
On 11 March 2020, the coronavirus disease (COVID-19) was defined by the World Health
Organization as a pandemic. Severe acute respiratory syndrome-2 (SARS-CoV-2) is the …

An update on current therapeutic drugs treating COVID-19

R Wu, L Wang, HCD Kuo, A Shannar, R Peter… - Current pharmacology …, 2020 - Springer
The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented …

A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development: IUPHAR Review 29

SPH Alexander, JF Armstrong… - British journal of …, 2020 - Wiley Online Library
In this review, we identify opportunities for drug discovery in the treatment of COVID‐19 and,
in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can …

After the hurricane: Anti-COVID-19 drugs development, molecular mechanisms of action and future perspectives

HO Khalifa, YM Al Ramahi - International Journal of Molecular Sciences, 2024 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a new coronavirus in
the Coronaviridae family. The COVID-19 pandemic, caused by SARS-CoV-2, has …

SARS-CoV-2 therapeutics: how far do we stand from a remedy?

A Singh, V Gupta - Pharmacological Reports, 2021 - Springer
The SARS-CoV-2 has affected millions worldwide and has posed an immediate need for
effective pharmacological interventions. Ever since the outbreak was declared, the medical …