Maternal adverse childhood experiences and biological aging during pregnancy and in newborns

CK Dye, DM Alschuler, H Wu, C Duarte… - JAMA Network …, 2024 - jamanetwork.com
Importance Adverse childhood experiences (ACEs), potentially traumatic experiences
occurring before the age of 18 years, are associated with epigenetic aging later in life and …

[HTML][HTML] Mother's childhood adversity is associated with accelerated epigenetic aging in pregnancy and in male newborns

CK Dye, H Wu, C Monk, DW Belsky, D Alschuler, S Lee… - BioRxiv, 2023 - ncbi.nlm.nih.gov
Background: Adverse childhood experiences (ACEs) are correlated with accelerated
epigenetic aging, but it is not clear whether altered epigenetic aging from childhood …

Epigenetic Biomarkers for Understanding Adverse Experiences and Health

AK Bozack, SM Merrill, A Cardenas - JAMA Network Open, 2024 - jamanetwork.com
Trauma and stress, particularly in early life, can have long-lasting implications on health and
wellbeing throughout the life course. Adverse childhood experiences (ACEs), such as …

[HTML][HTML] Maternal adverse childhood experiences before pregnancy are associated with epigenetic aging changes in their children

JC Nwanaji-Enwerem, L Van Der Laan, K Kogut… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Emerging research suggests associations of physical and psychosocial stressors with
epigenetic aging. Although this work has included early-life exposures, data on maternal …

Analysis of pregnancy complications and epigenetic gestational age of newborns

C Ladd-Acosta, E Vang, ES Barrett, CM Bulka… - JAMA Network …, 2023 - jamanetwork.com
Importance Preeclampsia, gestational hypertension, and gestational diabetes, the most
common pregnancy complications, are associated with substantial morbidity and mortality in …

Maternal psychosocial risk factors and child gestational epigenetic age in a South African birth cohort study

N Koen, MJ Jones, RT Nhapi, MT Lake… - Translational …, 2021 - nature.com
Accelerated epigenetic aging relative to chronological age has been found to be associated
with higher risk of mortality in adults. However, little is known about whether and how in …

Association of adverse childhood experiences with accelerated epigenetic aging in midlife

K Kim, K Yaffe, DH Rehkopf, Y Zheng… - JAMA network …, 2023 - jamanetwork.com
Importance Adverse childhood experiences (ACEs) are associated with the risk of poorer
health, and identifying molecular mechanisms may lay the foundation for health promotion in …

Maternal prenatal depression and epigenetic age deceleration: testing potentially confounding effects of prenatal stress and SSRI use

BG McKenna, CL Hendrix, PA Brennan, AK Smith… - Epigenetics, 2021 - Taylor & Francis
Previous studies suggest epigenetic alterations may contribute to the association between
maternal prenatal depression and adverse offspring outcomes. Developmental researchers …

Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu …

CP Ryan, RJ Rege, NR Lee, DB Carba, MS Kobor… - Clinical …, 2022 - Springer
Adverse birth outcomes, such as early gestational age and low birth weight, can have lasting
effects on morbidity and mortality, with impacts that persist into adulthood. Identifying the …

Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants

S Katrinli, AK Smith, SS Drury, J Covault, JD Ford… - Epigenetics, 2023 - Taylor & Francis
Pregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-
traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity …