[HTML][HTML] Counterpoint: Flow-mediated dilation does not reflect nitric oxide-mediated endothelial function

ME Tschakovsky, KE Pyke - Journal of applied physiology, 2005 - journals.physiology.org
The phenomenon of flow-mediated dilation (FMD) relevant to this debate describes the
vasodilation in a conduit vessel in response to elevations in flow-associated shear stress …

Point: Flow-mediated dilation does reflect nitric oxide-mediated endothelial function

D Green - Journal of Applied Physiology, 2005 - journals.physiology.org
Before you embark on this debate with my redoubtable Canadian friends, you may find it
advisable to take something to minimize your cardiovascular risk. I recommend the sensible …

Assessment of flow-mediated dilation in humans: a methodological and physiological guideline

DHJ Thijssen, MA Black, KE Pyke… - American Journal …, 2011 - journals.physiology.org
Endothelial dysfunction is now considered an important early event in the development of
atherosclerosis, which precedes gross morphological signs and clinical symptoms. The …

Is flow-mediated dilation nitric oxide mediated? A meta-analysis

DJ Green, EA Dawson, HMM Groenewoud, H Jones… - …, 2014 - Am Heart Assoc
Flow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular
health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this …

Flow-mediated dilation is associated with endothelial oxidative stress in human venous endothelial cells

AN Gurovich, JC Avery, NB Holtgrieve… - Vascular …, 2014 - journals.sagepub.com
Flow-mediated dilation (FMD) is recognized as a non-invasive endothelial function
bioassay. However, FMD's relationship with endothelial cell oxidative stress in humans is yet …

Flow-mediated dilation analysis coupled with nitric oxide transport to enhance the assessment of endothelial function

T Ma, X Liu, Q Ren, Z Zhang, X Sun… - Journal of Applied …, 2021 - journals.physiology.org
Flow-mediated dilation (FMD), mainly mediated by nitric oxide (NO), aims to assess the
shear-induced endothelial function, which is widely quantified by the relative change in …

The relationship between shear stress and flow‐mediated dilatation: implications for the assessment of endothelial function

KE Pyke, ME Tschakovsky - The Journal of physiology, 2005 - Wiley Online Library
Endothelium‐dependent flow‐mediated dilatation (FMD) describes the vasodilatory
response of a vessel to elevations in blood flow‐associated shear stress. Nitric oxide (NO) …

Flow-mediated dilation stimulated by sustained increases in shear stress: a useful tool for assessing endothelial function in humans?

JC Tremblay, KE Pyke - American Journal of Physiology …, 2018 - journals.physiology.org
Investigations of human conduit artery endothelial function via flow-mediated vasodilation
(FMD) have largely been restricted to the reactive hyperemia (RH) technique, wherein a …

Evaluation of endothelial function by flow mediated dilation: methodological issues and clinical importance

L Ghiadoni, M Salvetti, ML Muiesan… - High blood pressure & …, 2015 - Springer
Endothelium plays a primary role in the control of vascular function and structure by
protective properties of nitric oxide, which have stimulated the development of methods to …

Both flow-mediated dilation and constriction are associated with changes in blood flow and shear stress: two complementary perspectives on endothelial function

T Gori, U von Henning, S Muxel… - Clinical …, 2017 - journals.sagepub.com
INTRODUCTION: Flow-mediated dilation (FMD) quantifies endothelium-dependent
vasomotor responses to short-term increases in blood flow. Low-flow mediated …