[HTML][HTML] Neutralizing monoclonal antibodies for treatment of COVID-19

PC Taylor, AC Adams, MM Hufford… - Nature Reviews …, 2021 - nature.com
Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been developed and are now under evaluation in clinical …

SARS-CoV-2 neutralizing antibodies for COVID-19 prevention and treatment

D Li, GD Sempowski, KO Saunders… - Annual review of …, 2022 - annualreviews.org
Prophylactic and therapeutic drugs are urgently needed to combat coronavirus disease
2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

REGN-COV2, a neutralizing antibody cocktail, in outpatients with Covid-19

DM Weinreich, S Sivapalasingam… - … England Journal of …, 2021 - Mass Medical Soc
Background Recent data suggest that complications and death from coronavirus disease
2019 (Covid-19) may be related to high viral loads. Methods In this ongoing, double-blind …

A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Y Guo, L Huang, G Zhang, Y Yao, H Zhou… - Nature …, 2021 - nature.com
COVID-19 pandemic caused by SARS-CoV-2 constitutes a global public health crisis with
enormous economic consequences. Monoclonal antibodies against SARS-CoV-2 can …

Revealing the threat of emerging SARS-CoV-2 mutations to antibody therapies

J Chen, K Gao, R Wang, GW Wei - Journal of molecular biology, 2021 - Elsevier
The ongoing massive vaccination and the development of effective intervention offer the
long-awaited hope to end the global rage of the COVID-19 pandemic. However, the rapidly …

Analysis of immune escape variants from antibody-based therapeutics against COVID-19: a systematic review

D Focosi, F Maggi, M Franchini, S McConnell… - International journal of …, 2021 - mdpi.com
The accelerated SARS-CoV-2 evolution under selective pressure by massive deployment of
neutralizing antibody-based therapeutics is a concern with potentially severe implications for …

[HTML][HTML] Increased resistance of SARS-CoV-2 variants B. 1.351 and B. 1.1. 7 to antibody neutralization

D Ho, P Wang, L Liu, S Iketani, Y Luo, Y Guo, M Wang… - 2021 - europepmc.org
The Covid-19 pandemic has ravaged the globe, and its causative agent, SARS-CoV-2,
continues to rage. Prospects of ending this pandemic rest on the development of effective …

SARS-CoV-2 variants: A double-edged sword?

MP Jogalekar, A Veerabathini… - … Biology and Medicine, 2021 - journals.sagepub.com
Since the worldwide emergence of the COVID-19 outbreak, there have been international
concerns about the possible viral evolution into variants with underlying mutations that may …

[PDF][PDF] Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

AJ Greaney, TN Starr, P Gilchuk, SJ Zost, E Binshtein… - Cell host & …, 2021 - cell.com
Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being
developed as therapeutics and are a major contributor to neutralizing antibody responses …

SARS-CoV-2 variants B. 1.351 and B. 1.1. 248: Escape from therapeutic antibodies and antibodies induced by infection and vaccination

M Hoffmann, P Arora, R Groß, A Seidel, B Hörnich… - BioRxiv, 2021 - biorxiv.org
The global spread of SARS-CoV-2/COVID-19 is devastating health systems and economies
worldwide. Recombinant or vaccine-induced neutralizing antibodies are used to combat the …