Chronic hyperglycemia and oxidative stress in diabetes results in the formation and
accumulation advanced glycation end products (AGEs). AGEs have a wide range of …

Prolonged hyperglycemia, dyslipidemia and oxidative stress in diabetes result in the
increased production and accumulation of advanced glycation end products (AGEs) in the …

Nonenzymatic reactions between sugars and the free amino groups on proteins, lipids, and
nucleic acids result in molecular dysfunction through the formation of advanced glycation …

Advanced glycation end products (AGEs) are a heterogeneous group of molecules that
accumulate in plasma and tissues with advancing age, diabetes, and renal failure. There is …

Glycation is the process whereby sugars bind to the free amine residues of proteins. These
newly formed modified molecular species are known as 'advanced glycation end-products' …

Advanced glycation end products (AGEs) are a heterogeneous group of protein and lipids to
which sugar residues are covalently bound. AGE formation is increased in situations with …

Diabetic nephropathy is currently the single largest cause of endstage renal disease (ESRD)
in the United States and many European countries. The primary cause for the development …

The effect of ACE inhibition on the formation of advanced glycation end products (AGEs) and
oxidative stress was explored. Streptozocin-induced diabetic animals were randomized to …

Advanced glycation end products (AGE) contribute to diabetic tissue injury by two major
mechanisms, ie, the alteration of extracellular matrix architecture through nonenzymatic …

Several factors are incriminated in the genesis of diabetic nephropathy (DN). To elucidate
their interplays, we utilized a diabetic rat model with nephropathy (SHR/NDmcr-cp). This …